One Hundred Explicit Definitions of Potentially Inappropriate Prescriptions of Antibiotics in Hospitalized Older Patients: The Results of an Expert Consensus Study - Agents infectieux, résistance et chimiothérapie - UR UPJV 4294 Accéder directement au contenu
Article Dans Une Revue Antibiotics Année : 2024

One Hundred Explicit Definitions of Potentially Inappropriate Prescriptions of Antibiotics in Hospitalized Older Patients: The Results of an Expert Consensus Study

1 CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille]
2 GHICL - Groupement des Hôpitaux de l'Institut Catholique de Lille
3 UCL - Université catholique de Lille
4 Université de Lille
5 Centre Hospitalier Métropole Savoie [Chambéry]
6 CHUGA - Centre Hospitalier Universitaire [CHU Grenoble]
7 GREPI - Groupe de Recherche et d'Etude du Processus Inflammatoire
8 CHU Bordeaux
9 Inserm U1312 - BRIC - BoRdeaux Institute in onCology
10 Centre Hospitalier de Roubaix
11 Centre Hospitalier Gustave Dron [Tourcoing]
12 Centre Hospitalier Saint Jean de Perpignan
13 CHU ST-E - Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne]
14 GIMAP - Groupe Immunité des Muqueuses et Agents Pathogènes
15 CHIV - Centre Hospitalier Intercommunal Villeneuve-Saint-Georges
16 Service des Maladies Infectieuses et Tropicales [CHRU Nancy]
17 Service de maladies infectieuses [CH Melun]
18 DYNAMIC - Dynamic Microbiology - EA 7380
19 CHAC - Centre Hospitalier Alès-Cévennes
20 CHRU Brest - Centre Hospitalier Régional Universitaire de Brest
21 VIEFRA - EA 3797 - Vieillissement, Fragilité
22 CHU Reims - Hôpital universitaire Robert Debré [Reims]
23 Maladies infectieuses et tropicales [CHU Amiens]
24 AGIR - Agents infectieux, résistance et chimiothérapie - UR UPJV 4294
25 CHU de Poitiers [La Milétrie] - Centre hospitalier universitaire de Poitiers = Poitiers University Hospital
26 CIC 1402 - CIC Poitiers – Centre d'investigation clinique de Poitiers
27 Hôpitaux du Pays du Mont-Blanc
28 CHU Strasbourg - Centre Hospitalier Universitaire [Strasbourg]
Serge Alfandari
Thibaut Fraisse
Yvon Ruch

Résumé

Background: In geriatrics, explicit criteria for potentially inappropriate prescriptions (PIPs) are useful for optimizing drug use. Objective: To produce an expert consensus on explicit definitions of antibiotic-PIPs for hospitalized older patients. Methods: We conducted a Delphi survey involving French experts on antibiotic stewardship in hospital settings. During the survey’s rounds, the experts gave their opinion on each explicit definition, and could suggest new definitions. Definitions with a 1-to-9 Likert score of between 7 and 9 from at least 75% of the participants were adopted. The results were discussed during consensus meetings after each round. Results: Of the 155 invited experts, 128 (82.6%) participated in the whole survey: 59 (46%) infectious diseases specialists, 45 (35%) geriatricians, and 24 (19%) other specialists. In Round 1, 65 explicit definitions were adopted and 21 new definitions were suggested. In Round 2, 35 other explicit definitions were adopted. The results were validated during consensus meetings (with 44 participants after Round 1, and 54 after Round 2). Conclusions: The present study is the first to have provided a list of explicit definitions of potentially inappropriate antibiotic prescriptions for hospitalized older patients. It might help to disseminate key messages to prescribers and reduce inappropriate prescriptions of antibiotics.
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hal-04516422 , version 1 (04-06-2024)

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Nicolas Baclet, Emmanuel Forestier, Gaëtan Gavazzi, Claire Roubaud-Baudron, Vincent Hiernard, et al.. One Hundred Explicit Definitions of Potentially Inappropriate Prescriptions of Antibiotics in Hospitalized Older Patients: The Results of an Expert Consensus Study. Antibiotics, 2024, 13 (3), pp.283. ⟨10.3390/antibiotics13030283⟩. ⟨hal-04516422⟩
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