Using Real Time Phase contrast MRI to investigate CSF oscillations and aqueductal pressure gradients during free breathing
Résumé
Motivation
CSF dynamics is complex and regulates intracranial pressure. Pressure difference dynamics between the third and fourth ventricles (ΔPt) drives CSF oscillations in the aqueduct. MRI can quantify aqueduct anatomy and CSF oscillations.
Goal
To quantify ΔPt during free-breathing by combining MRI anatomical imaging with real-time phase-contrast MRI.
Approach
We developed a dedicated software to obtain: CSF flows dynamics Q(t), morphology of the aqueduct, its flow resistance (R) and ΔPt which equal Qt·R. Cardiac and breathing contributions to ΔPt were investigated in volunteers.
Results
Contributions to ΔPt were 12.3 Pa and 9.5 Pa from cardiac and breathing respectively.
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