Lessons from a large nationwide cohort of 350 children with ovarian mature teratoma: A study in favor of ovarian-sparing surgery - Université de Picardie Jules Verne Accéder directement au contenu
Article Dans Une Revue Pediatric Blood and Cancer Année : 2022

Lessons from a large nationwide cohort of 350 children with ovarian mature teratoma: A study in favor of ovarian-sparing surgery

1 CHU Caen
2 CHU Necker - Enfants Malades [AP-HP]
3 Imagine - U1163 - Imagine - Institut des maladies génétiques (IHU)
4 Service de pédiatrie, adolescents, jeunes adultes [Institut Curie]
5 GRAM 2.0 - Groupe de Recherche sur l'Adaptation Microbienne
6 Service d'hémato-immuno-oncologie pédiatrique [Rouen]
7 HFME - Hôpital Femme Mère Enfant [CHU - HCL]
8 HCL - Hospices Civils de Lyon
9 EPS - Environnement périnatal et croissance - EA 4489
10 Institut de Pathologie [CHU Lille]
11 CHU Pontchaillou [Rennes]
12 CRCINA-ÉQUIPE 4 - Immunogenic Cell Death and Mesothelioma Therapy
13 CHU ST-E - Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne]
14 CHRU Besançon - Centre Hospitalier Régional Universitaire de Besançon
15 CHU Angers - Centre Hospitalier Universitaire d'Angers
16 Laboratoire d’Histopathologie-Cytopathologie - Département de Pathologie Cellulaire et Tissulaire [CHU Angers]
17 CHU Amiens-Picardie
18 PERITOX - Périnatalité et Risques Toxiques - UMR INERIS_I 1
19 Service d'Hématologie biologique [CHU Limoges]
20 Service de Pédiatrie médicale [CHU Limoges]
21 Service de chirurgie pédiatrique [CHU Bordeaux]
22 Service de Chirurgie Viscerale et Urologie Pediatriques
23 USPC - Université Sorbonne Paris Cité
24 CRMERC - Maladies Endocriniennes Rares de la Croissance
25 U933 - Maladies génétiques d'expression pédiatrique
26 Riley Children's Hospital at Indiana University Health
27 Indiana University School of Medicine
28 UPD7 - Université Paris Diderot - Paris 7
29 CHU Trousseau [APHP]
30 AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre)
31 CHU Nantes - Centre hospitalier universitaire de Nantes
32 Service d'anatomie pathologique [CHU Necker]
33 ANTICIPE - Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers
34 Service de Pédiatrie Médicale [Caen]
Fanny Delehaye
  • Fonction : Auteur
Jeremie Rouger
  • Fonction : Auteur
Camille Duchesne
  • Fonction : Auteur
Solene Joseph
  • Fonction : Auteur
Marie Pierre Guibal
  • Fonction : Auteur
Claude Borionne
  • Fonction : Auteur


Background Ovarian mature teratoma (OMT) is a common ovarian tumor found in the pediatric population. In 10%-20% of cases, OMT occurs as multiple synchronous or metachronous lesions on ipsi- or contralateral ovaries. Ovarian-sparing surgery (OSS) is recommended to preserve fertility, but total oophorectomy (TO) is still performed. Design This study reviews the clinical data of patients with OMT, and analyzes risk factors for second events. A national retrospective review of girls under 18 years of age with OMTs was performed. Data on clinical features, imaging, laboratory studies, surgical reports, second events and their management were retrieved. Results Overall, 350 children were included. Eighteen patients (5%) presented with a synchronous bilateral form at diagnosis. Surgery was performed by laparotomy (85%) and laparoscopy (15%). OSS and TO were performed in 59% and 41% of cases, respectively. Perioperative tumor rupture occurred in 23 cases, independently of the surgical approach. Twenty-nine second events occurred (8.3%) in a median time of 30.5 months from diagnosis (ipsilateral: eight cases including one malignant tumor; contralateral: 18 cases; both ovaries: three cases). A large palpable mass, bilateral forms, at diagnosis and perioperative rupture had a statistical impact on the risk of second event, whereas the type of surgery or approach did not. Conclusion This study is a plea in favor of OSS as the first-choice treatment of OMT when possible. Close follow-up during the first 5 years is mandatory considering the risk of 8.3% of second events, especially in cases with risk factors.
Fichier non déposé

Dates et versions

hal-03553542 , version 1 (02-02-2022)



Fanny Delehaye, Sabine Sarnacki, Daniel Orbach, Alaa Cheikhelard, Jeremie Rouger, et al.. Lessons from a large nationwide cohort of 350 children with ovarian mature teratoma: A study in favor of ovarian-sparing surgery. Pediatric Blood and Cancer, 2022, 69 (3), ⟨10.1002/pbc.29421⟩. ⟨hal-03553542⟩
57 Consultations
0 Téléchargements



Gmail Facebook Twitter LinkedIn More