<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-03564802</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-02T14:32:24+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Abnormal laboratory findings and plasma concentration monitoring of lopinavir and ritonavir in COVID-19</title>
            <author role="aut">
              <persName>
                <forename type="first">Benjamin</forename>
                <surname>Batteux</surname>
              </persName>
              <email type="md5">381fb2c320298fe676fc5313dab8ce71</email>
              <email type="domain">u-picardie.fr</email>
              <idno type="idhal" notation="numeric">1235590</idno>
              <idno type="halauthorid" notation="string">1450876-1235590</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-9466-7110</idno>
              <idno type="IDREF">https://www.idref.fr/231466706</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/EKF-0617-2022</idno>
              <affiliation ref="#struct-300535"/>
              <affiliation ref="#struct-533000"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sandra</forename>
                <surname>Bodeau</surname>
              </persName>
              <email type="md5">10add785d71cc269d716ccee4a20ecb8</email>
              <email type="domain">u-picardie.fr</email>
              <idno type="idhal" notation="numeric">1150772</idno>
              <idno type="halauthorid" notation="string">2376484-1150772</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-7343-9212</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/AAK-9121-2020</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/CGT-5270-2022</idno>
              <idno type="IDREF">https://www.idref.fr/171549058</idno>
              <affiliation ref="#struct-300535"/>
              <affiliation ref="#struct-533000"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Valerie</forename>
                <surname>Gras-Champel</surname>
              </persName>
              <email type="md5">d7c2f7fe4df3be74c0eb734d7d867956</email>
              <email type="domain">chu-amiens.fr</email>
              <idno type="idhal" notation="numeric">1150827</idno>
              <idno type="halauthorid" notation="string">2419481-1150827</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/EQI-7450-2022</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/CRW-7293-2022</idno>
              <idno type="IDREF">https://www.idref.fr/076690563</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/EQI-7450-2022</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/CRW-7293-2022</idno>
              <affiliation ref="#struct-300535"/>
              <affiliation ref="#struct-533000"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sophie</forename>
                <surname>Liabeuf</surname>
              </persName>
              <email type="md5">5fd5ff0e6e60130b3a9b7b4e54c5766e</email>
              <email type="domain">u-picardie.fr</email>
              <idno type="idhal" notation="string">sophieliabeuf</idno>
              <idno type="idhal" notation="numeric">750529</idno>
              <idno type="halauthorid" notation="string">55196-750529</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-5384-9006</idno>
              <idno type="IDREF">https://www.idref.fr/081054882</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/AFB-7848-2022</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/CAH-7505-2022</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/AFB-7848-2022</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/CAH-7505-2022</idno>
              <affiliation ref="#struct-533000"/>
              <affiliation ref="#struct-300535"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jean-Philippe</forename>
                <surname>Lanoix</surname>
              </persName>
              <email type="md5">6bc323b842465c563c5d76b3e1d3a3f9</email>
              <email type="domain">chu-amiens.fr</email>
              <idno type="idhal" notation="string">jplanoix</idno>
              <idno type="idhal" notation="numeric">748225</idno>
              <idno type="halauthorid" notation="string">2071852-748225</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-0463-4636</idno>
              <idno type="IDREF">https://www.idref.fr/137758480</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/AAG-2048-2019</idno>
              <affiliation ref="#struct-560019"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jean-Luc</forename>
                <surname>Schmit</surname>
              </persName>
              <email type="md5">287d78614a3416b513b5802491f52952</email>
              <email type="domain">u-picardie.fr</email>
              <idno type="idhal" notation="numeric">1146074</idno>
              <idno type="halauthorid" notation="string">1161526-1146074</idno>
              <idno type="IDREF">https://www.idref.fr/074662236</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/FZI-6380-2022</idno>
              <affiliation ref="#struct-158208"/>
              <affiliation ref="#struct-560019"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Claire</forename>
                <surname>Andrejak</surname>
              </persName>
              <email type="md5">2e750071ea1bac851d2cd585fde124ea</email>
              <email type="domain">u-picardie.fr</email>
              <idno type="idhal" notation="string">claire-andrejak</idno>
              <idno type="idhal" notation="numeric">1144520</idno>
              <idno type="halauthorid" notation="string">2238886-1144520</idno>
              <idno type="IDREF">https://www.idref.fr/11107410X</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-9998-8578</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/CDO-9091-2022</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/CDO-9091-2022</idno>
              <orgName ref="#struct-300258"/>
              <affiliation ref="#struct-560019"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Yoann</forename>
                <surname>Zerbib</surname>
              </persName>
              <email type="md5">98c970525aeaa7fc49e6f67c069fc1f2</email>
              <email type="domain">chu-amiens.fr</email>
              <idno type="idhal" notation="numeric">1526903</idno>
              <idno type="halauthorid" notation="string">2530367-1526903</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-9937-6096</idno>
              <idno type="IDREF">https://www.idref.fr/195565320</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/GJC-8470-2022</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/GJC-8470-2022</idno>
              <affiliation ref="#struct-300258"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Guillaume</forename>
                <surname>Haye</surname>
              </persName>
              <email type="md5">6a95b53bb17e57c154d838bd1dced3d5</email>
              <email type="domain">chu-amiens.fr</email>
              <idno type="idhal" notation="numeric">1496901</idno>
              <idno type="halauthorid" notation="string">2424831-1496901</idno>
              <idno type="IDREF">https://www.idref.fr/237775123</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Kamel</forename>
                <surname>Masmoudi</surname>
              </persName>
              <email type="md5">bbdb7dc5758d9795321ac0dbf03b7fa5</email>
              <email type="domain">chu-amiens.fr</email>
              <idno type="idhal" notation="numeric">1512152</idno>
              <idno type="halauthorid" notation="string">2382835-1512152</idno>
              <idno type="IDREF">https://www.idref.fr/11252821X</idno>
              <affiliation ref="#struct-300535"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Anne-Sophie</forename>
                <surname>Lemaire-Hurtel</surname>
              </persName>
              <email type="md5">7019d7027b5ce71a3d1612d43e4b044d</email>
              <email type="domain">chu-amiens.fr</email>
              <idno type="idhal" notation="numeric">1497812</idno>
              <idno type="halauthorid" notation="string">1788536-1497812</idno>
              <idno type="IDREF">https://www.idref.fr/098445618</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-6417-2149</idno>
              <affiliation ref="#struct-300535"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Youssef</forename>
                <surname>Bennis</surname>
              </persName>
              <email type="md5">4a1727de96d4cf3b52fb530f4d17ae6c</email>
              <email type="domain">u-picardie.fr</email>
              <idno type="idhal" notation="string">youssef-bennis</idno>
              <idno type="idhal" notation="numeric">780775</idno>
              <idno type="halauthorid" notation="string">1120770-780775</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-0186-4797</idno>
              <idno type="IDREF">https://www.idref.fr/146710401</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/ABC-8816-2020</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/F-3662-2015</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/ABC-8816-2020</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/F-3662-2015</idno>
              <affiliation ref="#struct-300535"/>
              <affiliation ref="#struct-533000"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Louise</forename>
                <surname>DESSAIVRE</surname>
              </persName>
              <email type="md5">685d55eef963fb90de2023edc9d11c27</email>
              <email type="domain">u-picardie.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2022-02-10 15:58:57</date>
              <date type="whenModified">2025-04-01 16:41:34</date>
              <date type="whenReleased">2022-02-10 15:58:57</date>
              <date type="whenProduced">2021</date>
              <ref type="externalLink" target="https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bcp.14489"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="799781">
                <persName>
                  <forename>Louise</forename>
                  <surname>DESSAIVRE</surname>
                </persName>
                <email type="md5">685d55eef963fb90de2023edc9d11c27</email>
                <email type="domain">u-picardie.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-03564802</idno>
            <idno type="halUri">https://u-picardie.hal.science/hal-03564802</idno>
            <idno type="halBibtex">batteux:hal-03564802</idno>
            <idno type="halRefHtml">&lt;i&gt;British Journal of Clinical Pharmacology&lt;/i&gt;, 2021, 87 (3), pp.1547-1553. &lt;a target="_blank" href="https://dx.doi.org/10.1111/bcp.14489"&gt;&amp;#x27E8;10.1111/bcp.14489&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">British Journal of Clinical Pharmacology, 2021, 87 (3), pp.1547-1553. &amp;#x27E8;10.1111/bcp.14489&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="UNIV-PICARDIE">Université de Picardie Jules Verne</idno>
            <idno type="stamp" n="U-PICARDIE">Université de Picardie Jules Verne</idno>
            <idno type="stamp" n="MP3CV" corresp="U-PICARDIE">Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517</idno>
            <idno type="stamp" n="AGIR-UPJV" corresp="U-PICARDIE">Agents infectieux, résistance et chimiothérapie - UR UPJV 4294</idno>
            <idno type="stamp" n="TEST3-HALCNRS">TEST3-HALCNRS</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Abnormal laboratory findings and plasma concentration monitoring of lopinavir and ritonavir in COVID-19</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Benjamin</forename>
                    <surname>Batteux</surname>
                  </persName>
                  <email type="md5">381fb2c320298fe676fc5313dab8ce71</email>
                  <email type="domain">u-picardie.fr</email>
                  <idno type="idhal" notation="numeric">1235590</idno>
                  <idno type="halauthorid" notation="string">1450876-1235590</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-9466-7110</idno>
                  <idno type="IDREF">https://www.idref.fr/231466706</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/EKF-0617-2022</idno>
                  <affiliation ref="#struct-300535"/>
                  <affiliation ref="#struct-533000"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sandra</forename>
                    <surname>Bodeau</surname>
                  </persName>
                  <email type="md5">10add785d71cc269d716ccee4a20ecb8</email>
                  <email type="domain">u-picardie.fr</email>
                  <idno type="idhal" notation="numeric">1150772</idno>
                  <idno type="halauthorid" notation="string">2376484-1150772</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-7343-9212</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/AAK-9121-2020</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/CGT-5270-2022</idno>
                  <idno type="IDREF">https://www.idref.fr/171549058</idno>
                  <affiliation ref="#struct-300535"/>
                  <affiliation ref="#struct-533000"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Valerie</forename>
                    <surname>Gras-Champel</surname>
                  </persName>
                  <email type="md5">d7c2f7fe4df3be74c0eb734d7d867956</email>
                  <email type="domain">chu-amiens.fr</email>
                  <idno type="idhal" notation="numeric">1150827</idno>
                  <idno type="halauthorid" notation="string">2419481-1150827</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/EQI-7450-2022</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/CRW-7293-2022</idno>
                  <idno type="IDREF">https://www.idref.fr/076690563</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/EQI-7450-2022</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/CRW-7293-2022</idno>
                  <affiliation ref="#struct-300535"/>
                  <affiliation ref="#struct-533000"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sophie</forename>
                    <surname>Liabeuf</surname>
                  </persName>
                  <email type="md5">5fd5ff0e6e60130b3a9b7b4e54c5766e</email>
                  <email type="domain">u-picardie.fr</email>
                  <idno type="idhal" notation="string">sophieliabeuf</idno>
                  <idno type="idhal" notation="numeric">750529</idno>
                  <idno type="halauthorid" notation="string">55196-750529</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-5384-9006</idno>
                  <idno type="IDREF">https://www.idref.fr/081054882</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/AFB-7848-2022</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/CAH-7505-2022</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/AFB-7848-2022</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/CAH-7505-2022</idno>
                  <affiliation ref="#struct-533000"/>
                  <affiliation ref="#struct-300535"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean-Philippe</forename>
                    <surname>Lanoix</surname>
                  </persName>
                  <email type="md5">6bc323b842465c563c5d76b3e1d3a3f9</email>
                  <email type="domain">chu-amiens.fr</email>
                  <idno type="idhal" notation="string">jplanoix</idno>
                  <idno type="idhal" notation="numeric">748225</idno>
                  <idno type="halauthorid" notation="string">2071852-748225</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-0463-4636</idno>
                  <idno type="IDREF">https://www.idref.fr/137758480</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/AAG-2048-2019</idno>
                  <affiliation ref="#struct-560019"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean-Luc</forename>
                    <surname>Schmit</surname>
                  </persName>
                  <email type="md5">287d78614a3416b513b5802491f52952</email>
                  <email type="domain">u-picardie.fr</email>
                  <idno type="idhal" notation="numeric">1146074</idno>
                  <idno type="halauthorid" notation="string">1161526-1146074</idno>
                  <idno type="IDREF">https://www.idref.fr/074662236</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/FZI-6380-2022</idno>
                  <affiliation ref="#struct-158208"/>
                  <affiliation ref="#struct-560019"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Claire</forename>
                    <surname>Andrejak</surname>
                  </persName>
                  <email type="md5">2e750071ea1bac851d2cd585fde124ea</email>
                  <email type="domain">u-picardie.fr</email>
                  <idno type="idhal" notation="string">claire-andrejak</idno>
                  <idno type="idhal" notation="numeric">1144520</idno>
                  <idno type="halauthorid" notation="string">2238886-1144520</idno>
                  <idno type="IDREF">https://www.idref.fr/11107410X</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-9998-8578</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/CDO-9091-2022</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/CDO-9091-2022</idno>
                  <orgName ref="#struct-300258"/>
                  <affiliation ref="#struct-560019"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Yoann</forename>
                    <surname>Zerbib</surname>
                  </persName>
                  <email type="md5">98c970525aeaa7fc49e6f67c069fc1f2</email>
                  <email type="domain">chu-amiens.fr</email>
                  <idno type="idhal" notation="numeric">1526903</idno>
                  <idno type="halauthorid" notation="string">2530367-1526903</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-9937-6096</idno>
                  <idno type="IDREF">https://www.idref.fr/195565320</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/GJC-8470-2022</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/GJC-8470-2022</idno>
                  <affiliation ref="#struct-300258"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Guillaume</forename>
                    <surname>Haye</surname>
                  </persName>
                  <email type="md5">6a95b53bb17e57c154d838bd1dced3d5</email>
                  <email type="domain">chu-amiens.fr</email>
                  <idno type="idhal" notation="numeric">1496901</idno>
                  <idno type="halauthorid" notation="string">2424831-1496901</idno>
                  <idno type="IDREF">https://www.idref.fr/237775123</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Kamel</forename>
                    <surname>Masmoudi</surname>
                  </persName>
                  <email type="md5">bbdb7dc5758d9795321ac0dbf03b7fa5</email>
                  <email type="domain">chu-amiens.fr</email>
                  <idno type="idhal" notation="numeric">1512152</idno>
                  <idno type="halauthorid" notation="string">2382835-1512152</idno>
                  <idno type="IDREF">https://www.idref.fr/11252821X</idno>
                  <affiliation ref="#struct-300535"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Anne-Sophie</forename>
                    <surname>Lemaire-Hurtel</surname>
                  </persName>
                  <email type="md5">7019d7027b5ce71a3d1612d43e4b044d</email>
                  <email type="domain">chu-amiens.fr</email>
                  <idno type="idhal" notation="numeric">1497812</idno>
                  <idno type="halauthorid" notation="string">1788536-1497812</idno>
                  <idno type="IDREF">https://www.idref.fr/098445618</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-6417-2149</idno>
                  <affiliation ref="#struct-300535"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Youssef</forename>
                    <surname>Bennis</surname>
                  </persName>
                  <email type="md5">4a1727de96d4cf3b52fb530f4d17ae6c</email>
                  <email type="domain">u-picardie.fr</email>
                  <idno type="idhal" notation="string">youssef-bennis</idno>
                  <idno type="idhal" notation="numeric">780775</idno>
                  <idno type="halauthorid" notation="string">1120770-780775</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-0186-4797</idno>
                  <idno type="IDREF">https://www.idref.fr/146710401</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/ABC-8816-2020</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/F-3662-2015</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/ABC-8816-2020</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/F-3662-2015</idno>
                  <affiliation ref="#struct-300535"/>
                  <affiliation ref="#struct-533000"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">11316</idno>
                <idno type="issn">0306-5251</idno>
                <idno type="eissn">1365-2125</idno>
                <title level="j">British Journal of Clinical Pharmacology</title>
                <imprint>
                  <publisher>Wiley</publisher>
                  <biblScope unit="volume">87</biblScope>
                  <biblScope unit="issue">3</biblScope>
                  <biblScope unit="pp">1547-1553</biblScope>
                  <date type="datePub">2021</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1111/bcp.14489</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>It is not known whether the adverse events (AEs) associated with the administration of lopinavir and ritonavir (LPV/r) in the treatment of COVID-19 are concentration-dependent. In a retrospective study of 65 patients treated with LPV/r and therapeutic drug monitoring (TDM) for severe forms of COVID-19 (median age: 67; males: 41 [63.1%]), 33 (50.8%) displayed a grade &gt;= 2 increase in plasma levels of hepatobiliary markers, lipase and/or triglycerides. A causal relationship between LPV/r and the AE was suspected in 9 of the 65 patients (13.8%). At 400 mg b.i.d., the plasma trough concentrations of LPV/r were high and showed marked interindividual variability (median [interquartile range]: 16,600 [11,430-20,842] ng/ml for lopinavir and 501 [247-891] ng/ml for ritonavir). The trough lopinavir concentration was negatively correlated with body mass index, while the trough ritonavir concentration was positively correlated with age and negatively correlated with prothrombin activity. However, the occurrence of abnormal laboratory values was not associated with higher trough plasma concentrations of LPV/r. Further studies will be needed to determine the value of TDM in LPV/r-treated patients with COVID-19.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="institution" xml:id="struct-300535" status="VALID">
          <orgName>CHU Amiens-Picardie</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-533000" status="VALID">
          <idno type="IdRef">195403800</idno>
          <idno type="RNSR">201220168Z</idno>
          <idno type="ROR">https://ror.org/00bgnvd66</idno>
          <orgName>Mécanismes physiopathologiques et conséquences des calcifications cardiovasculaires - UR UPJV 7517</orgName>
          <orgName type="acronym">MP3CV</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>Université de Picardie Jules Verne - Centre de Recherche Universitaire en Santé (CURS) - CHU Sud - rue Renée Laennec - 80054 Amiens Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://mp3cv.u-picardie.fr/accueil-mp3cv-422954.kjsp</ref>
          </desc>
          <listRelation>
            <relation name="UR7517" active="#struct-300258" type="direct"/>
            <relation name="U1088" active="#struct-300535" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-560019" status="VALID">
          <idno type="IdRef">241967309</idno>
          <idno type="RNSR">201822701B</idno>
          <idno type="ROR">https://ror.org/04mywez65</idno>
          <orgName>Agents infectieux, résistance et chimiothérapie - UR UPJV 4294</orgName>
          <orgName type="acronym">AGIR</orgName>
          <date type="start">2018-01-01</date>
          <desc>
            <address>
              <addrLine>Université de Picardie Jules Verne - CURS - CHU Sud avenue Laënnec - 80054 AMIENS CEDEX1</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation name="UR4294" active="#struct-300258" type="direct"/>
            <relation active="#struct-300535" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-158208" status="VALID">
          <orgName>Laboratoire de Virologie [CHU Amiens]</orgName>
          <desc>
            <address>
              <addrLine>CHU Amiens-Picardie – Site Sud (entrée principale) - 1 Rond-Point du Professeur Christian Cabrol - 80054 Amiens cedex 1</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300535" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300258" status="VALID">
          <idno type="IdRef">026403714</idno>
          <idno type="ISNI">0000 0001 0789 1385</idno>
          <idno type="ROR">https://ror.org/01gyxrk03</idno>
          <orgName>Université de Picardie Jules Verne</orgName>
          <orgName type="acronym">UPJV</orgName>
          <desc>
            <address>
              <addrLine>Chemin du Thil - 80000 Amiens</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.u-picardie.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>