%0 Journal Article %T Severe acute alcoholic hepatitis %+ CHU Amiens-Picardie %+ Groupe de Recherche sur l'alcool et les pharmacodépendances - UMR INSERM_S 1247 (GRAP) %+ Polyclinique Saint-Claude %+ CHirurgie, IMagerie et REgénération tissulaire de l’extrémité céphalique - Caractérisation morphologique et fonctionnelle - UR UPJV 7516 (CHIMERE) %+ Département de chirurgie maxillofaciale et stomatologie [CHU d'Amiens-Picardie] %+ Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV) %A Nguyen-Khac, E. %A Dejour, V. %A Sarba, R. %A Yzet, T. %A Turpin, J. %A Chatelain, D. %A Marcq, I. %A Chivot, C. %A Maizel, Julien %A Papillon, C. A. %A Attencourt, C. %A Houchi, H. %< avec comité de lecture %@ 2496-6142 %J Médecine Intensive Réanimation %I Société de Réanimation de langue française %V 27 %N 6 %P 510-521 %8 2018 %D 2018 %R 10.3166/rea-2018-0069 %Z Life Sciences [q-bio]Journal articles %X All the chronic and excessive consumers of alcohol with recent jaundice should be assessed using a Maddrey's score for severe acute alcoholic hepatitis. Corticosteroids are the first-line treatment associated with an appropriate nutritional support and alcohol abstinence. Corticosteroids plus N-acetylcysteine combination improves short-term survival over corticosteroids alone, and could be proposed as a first-line therapy. The response to treatment is evaluated at the 7th day of treatment, with the Lille model <= 0.45. Prognostic of non-responders to corticosteroids with Lille model > 0.45 is dramatically low with 23% survival at 6 months. Early liver transplantation in a selected group of patients with non-response to corticosteroids significantly improves at sixth-month and is long-term survival. %G English %L hal-03577868 %U https://u-picardie.hal.science/hal-03577868 %~ UNIV-PICARDIE %~ U-PICARDIE %~ CHIMERE %~ MP3CV %~ GRAP %~ TEST3-HALCNRS