%0 Journal Article %T Clinical Outcomes of Adults With Bicuspid Aortic Valve: A European Perspective %+ Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV) %+ CHU Amiens-Picardie %+ Université de Picardie Jules Verne (UPJV) %A Cheng, Charles %A Bohbot, Yohann %A Michelena, Hector %A Rusinaru, Dan %A Fay, Floriane %A Elmkies, Frederic %A Sarano, Maurice Enriquez %A Tribouilloy, Christophe %< avec comité de lecture %@ 0025-6196 %J Mayo Clinic Proceedings %I Elsevier %V 96 %N 3 %P 648-657 %8 2021 %D 2021 %R 10.1016/j.mayocp.2020.04.047 %Z Life Sciences [q-bio]Journal articles %X Objective: To describe the clinical history of patients with a wide age range diagnosed with bicuspid aortic valve (BAV) and no surgical indication and to evaluate the long-term outcome of patients with BAV referred for elective surgery. Patients and Methods: Between 2005 and 2017, 350 consecutive patients with no surgical indication (surveillance group, mean age 53 +/- 16, 71% men) and 191 with a surgical indication (surgical group, mean age 59 +/- 13, 71% men) were prospectively included. Median follow-up was 80 (32 to 115) months. Results: In the surveillance group, the 5-year and 10-year survival rates were 93 +/- 1% and 89 +/- 2%, respectively, with a relative survival of patients with BAV compared with an age- and sex-matched control population of 98.7%. During follow-up, the cumulative 10-year incidence of aortic valve and aorta surgery was high; of 35 +/- 4%, the incidence of native valve infective endocarditis (IE) of 0.2% per patient-year, and no cases of aortic dissection were observed. In the surgical group, the 5-year and 10-year survival rates were 97 +/- 1% and 89 +/- 3%, respectively, with a relative survival of 99.4% compared with the general population. The incidence of IE was 0.4% per patient-year, and no cases of aortic dissection were observed. Conclusion: This regional cohort shows that the 10-year survival rates of patients with BAV and a wide age range, but mostly middle-aged adults, were similar to those of the general population with a very low rate of complications. Adherence to prophylactic surgical indications and younger age might have contributed to this lack of difference. (C) 2020 Mayo Foundation for Medical Education and Research %G English %2 https://u-picardie.hal.science/hal-03579643/document %2 https://u-picardie.hal.science/hal-03579643/file/S0025619620308442.pdf %L hal-03579643 %U https://u-picardie.hal.science/hal-03579643 %~ UNIV-PICARDIE %~ U-PICARDIE %~ MP3CV %~ ELSEVIER