%0 Journal Article %T Prognostic value of left ventricular reverse remodeling and performance improvement after cardiac resynchronization therapy: A prospective study %+ Université catholique de Lille (UCL) %+ Mécanismes physiologiques et conséquences des calcifications cardiovasculaires: rôle des remodelages cardiovasculaires et osseux %+ Département de cardiologie et hypertension %+ Institut Droit et Santé (IDS - U1145) %+ Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV) %+ Groupement Hospitalier de l'Institut Catholique de Lille %A Menet, Aymeric %A Guyomar, Yves %A Ennezat, Pierre-Vladimir %A Graux, Pierre %A Castel, Anne Laure %A Delelis, Francois %A Heuls, Sebastien %A Cuvelier, Estelle %A Gevaert, Cecile %A Le Goffic, Caroline %A Tribouilloy, Christophe %A Marechaux, Sylvestre %< avec comité de lecture %@ 0167-5273 %J International Journal of Cardiology %I Elsevier %V 204 %P 6-11 %8 2016 %D 2016 %R 10.1016/j.ijcard.2015.11.091 %Z Life Sciences [q-bio]Journal articles %X Background: The present study was designed to evaluate the respective value of left ventricular (LV) reverse remodeling (changes in LV end-systolic volume relative to baseline (Delta LVESV)) or LV performance improvement (Delta LV ejection fraction (Delta LVEF) or Delta Global longitudinal strain (GLS)) to predict long-termoutcome in a prospective cohort of consecutive patients receiving routine cardiac resynchronization therapy (CRT). Methods: One hundred and seventy heart failure patients (NYHA classes II-IV, LVEF <= 35%, QRS width >= 120 ms) underwent echocardiography before and 9 months after CRT. The relationships between Delta LVESV, Delta LVEF, Delta GLS and outcome (all-cause mortality and/or CHF hospitalization, overall mortality, cardiovascular mortality, CHF hospitalization) were investigated. Results: During a median follow-up of 32 months, 20 patients died and 27 were hospitalized for heart failure. Delta LVESV, Delta LVEF or Delta GLS were significantly associated with all-cause mortality or CHF hospitalization (adjusted hazard's ratio (HR) per standard deviation 0.58 (0.43-0.77), 0.39 (0.27-0.57) or 0.55 (0.37-0.83) respectively, all p < 0.01) and all other endpoints (all p < 0.01). Patients with Delta LVESV >= 15%, Delta LVEF >= 10% and Delta GLS >= 1% had a reduced risk of mortality or CHF hospitalization (adjusted HR = 0.25 (0.12-0.51), p < 0.001, adjusted HR = 0.26 (0.13-0.54), p < 0.001 and adjusted HR0.38 (0.19-0.75), p=0.006 respectively). Overall performance of multivariate models was better using Delta LVESV or Delta LVEF compared with Delta GLS. Interobserver agreement was excellent for Delta LVESV (Intraclass correlation coefficient -ICC-0.91) and Delta GLS (ICC 0.90) but modest for.LVEF (ICC 0.76) in a sample of 20 patients from the study population. Conclusions: LV reverse remodeling assessed by Delta LVESV is a strong and reproducible predictor of outcome following CRT. Compared with Delta LVESV, Delta LVEF and Delta GLS have important shortcomings: poorer reproducibility or lower predictive value. (C) 2015 Elsevier Ireland Ltd. All rights reserved. %G English %L hal-03580786 %U https://u-picardie.hal.science/hal-03580786 %~ UNIV-PARIS5 %~ UNIV-PICARDIE %~ USPC %~ INSTITUT-DROIT-SANTE %~ UNIV-PARIS %~ UP-SOCIETES-HUMANITES %~ U-PICARDIE %~ MP3CV %~ UNIV-CATHOLILLE %~ ICL %~ FMMS