%0 Journal Article %T Heart Transplantation for Peripartum Cardiomyopathy: A Single-Center Experience %+ CHU Pitié-Salpêtrière [AP-HP] %+ Université Pierre et Marie Curie - Paris 6 (UPMC) %+ Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV) %+ Sorbonne Université (SU) %+ Institut de cardiologie [CHU Pitié-Salpêtrière] %+ Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN) %+ Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille) %A Bouabdallaoui, Nadia %A Demondion, Pierre %A Marechaux, Sylvestre %A Varnous, Shaida %A Lebreton, Guillaume %A Mouquet, Frederic %A Leprince, Pascal %< avec comité de lecture %@ 0066-782X %J Arquivos Brasileiros de Cardiologia %I Sociedade Brasileira de Cardiologia - SBC %V 110 %N 2 %P 181-187 %8 2018 %D 2018 %R 10.5935/abc.20180014 %Z Life Sciences [q-bio]Journal articles %X Background: Peripartum cardiomyopathy is an idiopathic disorder defined by the occurrence of acute heart failure during late pregnancy or post-partum period in the absence of any other definable cause. Its clinical course is variable and severe cases might require heart transplantation. Objective: To investigate long-term outcomes after heart transplantation (HT) for peripartum cardiomyopathy (PPCM). Methods: Out of a single-center series of 1938 HT, 14 HT were performed for PPCM. We evaluated clinical characteristics, transplant-related complications, and long-term outcomes, in comparison with 28 sex-matched controls. Primary endpoint was death from any cause; secondary endpoints were transplant-related complications (rejection, infection, cardiac allograft vasculopathy). A value of p < 0.05 was considered of statistical significance. Results: PPCM patients and matched controls were comparable for most variables (all p values > 0.05), except for a higher use of inotropes at the time of HT in PPCM group (p = 0.03). During a median follow-up of 7.7 years, 16 patients died, 3 (21.5%) in PPCM group and 13 (46.5%) in control group. Mortality was significantly lower in PPCM group (p = 0.03). No significant difference was found in terms of transplant-related complications (p > 0.05). Conclusions: Long-term outcomes following HT for PPCM are favorable. Heart transplantation is a valuable option for PPCM patients who did not recover significantly under medical treatment. %G English %L hal-03583845 %U https://u-picardie.hal.science/hal-03583845 %~ INSERM %~ UNIV-PICARDIE %~ APHP %~ ICAN %~ SORBONNE-UNIVERSITE %~ SORBONNE-UNIV %~ SU-MEDECINE %~ SU-MED %~ SU-TI %~ U-PICARDIE %~ MP3CV %~ ALLIANCE-SU %~ IHU_ICAN