%0 Journal Article %T The Multi-center Evaluation of the Accuracy of the Contrast MEdium INduced Pd/Pa RaTiO in Predicting FFR (MEMENTO-FFR) Study %+ Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma] (Unicatt) %+ Hospital Universitario Fundación Jiménez Díaz [Madrid, Spain] %+ Hospital Prof Doutor Fernando Fonseca [Amadora, Portugal] %+ Institut Mutualiste de Montsouris (IMM) %+ Hospital De Egas Moniz [Lisbon] %+ AP-HP - Hôpital Antoine Béclère [Clamart] %+ Hôpital Lariboisière-Fernand-Widal [APHP] %+ Université Paris Diderot - Paris 7 (UPD7) %+ Hospital Clinico Universitario de Valladolid [Castilla y León, Spain] (HCUV) %+ Hospital Universitario Marqués de Valdecilla [Santander] %A Leone, Antonio Maria %A Martin-Reyes, Roberto %A Baptista, Sergio B. %A Amabile, Nicolas %A Raposos, Luis %A Franco Pelaez, Juan Antonio %A Trani, Carlo %A Cialdella, Pio %A Basile, Eloisa %A Zimbardo, Giuseppe %A Burzotta, Francesco %A Porto, Italo %A Aurigemma, Cristina %A Rebuzzi, Antonio G. %A Faustino, Mariana %A Niccoli, Giampaolo %A Abreu, Pedro F. %A Slama, Michel %A Spagnoli, Vincent %A Telleria Arrieta, Miren %A Amat Santos, Ignacio J. %A Tone Hernandez, Jose M., de La %A Lopez Palop, Ramon %A Crea, Filippo %< avec comité de lecture %@ 1774-024X %J EuroIntervention %I EuroPCR %V 12 %N 6 %P 708-715 %8 2016 %D 2016 %R 10.4244/EIJV12I6A115 %M 27542782 %Z Life Sciences [q-bio]Journal articles %X Aims: Adenosine administration is needed for the achievement of maximal hyperaemia fractional flow reserve (FFR) assessment. The objective was to test the accuracy of Pd/Pa ratio registered during sub maximal hyperaemia induced by non-ionic contrast medium (contrast FFR [cFFR]) in predicting FFR and comparing it to the performance of resting Pd/Pa in a collaborative registry of 926 patients enrolled in 10 hospitals from four European countries (Italy, Spain, France and Portugal). Methods and results: Resting Pd/Pa, cFFR and FFR were measured in 1,026 coronary stenoses functionally evaluated using commercially available pressure wires. cFFR was obtained after intracoronary injection of contrast medium, while FFR was measured after administration of adenosine. Resting Pd/Pa and cFFR were significantly higher than FFR (0.93 +/- 0.05 vs. 0.87 +/- 0.08 vs. 0.84 +/- 0.08, p<0.001). A strong correlation and a close agreement at Bland-Altman analysis between cFFR and FFR were observed (r=0.90, p<0.001 and 95% CI of disagreement: from -0.042 to 0.11). ROC curve analysis showed an excellent accuracy (89%) of the cFFR cut-off of <= 0.85 in predicting an FFR value <= 0.80 (AUC 0.95 [95% CI: 0.94-0.96]), significantly better than that observed using resting Pd/Pa (AUC: 0.90, 95% CI: 0.88-0.91; p<0.001). A cFFR/FFR hybrid approach showed a significantly lower number of lesions requiring adenosine than a resting Pd/Pa/FFR hybrid approach (22% vs. 44%, p<0.0001). Conclusions: cFFR is accurate in predicting the functional significance of coronary stenosis. This could allow limiting the use of adenosine to obtain FFR to a minority of stenoses with considerable savings of time and costs. %G English %L hal-03584167 %U https://u-picardie.hal.science/hal-03584167 %~ UNIV-PARIS7 %~ APHP %~ USPC %~ CHU-UNIV-PARIS5 %~ UNIV-PARIS %~ U-PICARDIE %~ MP3CV