%0 Journal Article %T Treatment of Bone and Joint Tuberculosis in France: A Multicentre Retrospective Study %+ Centre Hospitalier Universiatire Hôtel-Dieu de Nantes (CHU Hôtel-Dieu) %+ CHU Amiens-Picardie %+ Agents infectieux, résistance et chimiothérapie - UR UPJV 4294 (AGIR ) %+ CHU Bordeaux [Bordeaux] %+ Génétique, génomique fonctionnelle et biotechnologies (UMR 1078) (GGB) %+ Centre Hospitalier Régional Universitaire de Tours (CHRU Tours) %+ Infectiologie et Santé Publique (UMR ISP) %+ Thérapeutiques cliniques et expérimentales des infections (EA 3826) (EA 3826) %+ Hôpital Pontchaillou %+ Centre de référence en infections ostéo-articulaires du grand-ouest [Rennes] (CRIOGO) %+ Centre hospitalier universitaire de Nantes (CHU Nantes) %+ Microbiotes, Hôtes, Antibiotiques et Résistances bactériennes (MiHAR) (MiHAR) %A Guillouzouic, Aurelie %A Andrejak, Claire %A Peuchant, Olivia %A Hery-Arnaud, Genevieve %A Hamdad, Farida %A Lanotte, Philippe %A Gaborit, Benjamin %A Bernard, Louis %A Bemer, Pascale %< avec comité de lecture %@ 2077-0383 %J Journal of Clinical Medicine %I MDPI %V 9 %N 8 %P 12 p. %8 2020 %D 2020 %R 10.3390/jcm9082529 %K spinal tuberculosis %K extraspinal tuberculosis %K bone and joint tuberculosis %K diagnosis %K treatment duration %Z Life Sciences [q-bio]Journal articles %X Background: Nine percent of all cases of tuberculosis are bone and joint tuberculosis (BJTB). BJTB occurs in two main forms: spinal (STB) and extraspinal (ESTB). The aim of this study was to compare STB with ESTB in terms of diagnosis, treatment and outcomes. Methods: We collected demographic, clinical, microbiological, treatment duration and outcome data for patients with BJTB in a retrospective multicentre study over a 17-year period. Results: Of the 116 patients included in the study, 69 (59.5%) had STB and 47 (40.5%) had ESTB. The median age was higher in the ESTB group. There were significantly more foreign-born patients in the STB group. The median time for diagnosis was longer for ESTB (6 months) than STB (4 months) (p= 0.017). Magnetic resonance imaging was highly reliable for the diagnosis. Direct examination and histology allowed the diagnosis to be made in more than 80% of cases. The median treatment duration of 12 months, regardless of the type of BJTB, was longer than recommended. A favourable outcome was achieved in 91.9% of cases. Conclusion: The management of BJTB remains challenging. An earlier diagnosis should be more effective, reducing the total duration of treatment and leading to better tolerance. %G English %L hal-03591322 %U https://u-picardie.hal.science/hal-03591322 %~ UNIV-BREST %~ UNIV-NANTES %~ UNIV-TOURS %~ UNIV-PICARDIE %~ HL %~ CHU-UNIV-PARIS5 %~ GGFB %~ IBSAM %~ MIHAR-NANTES %~ INRAE %~ U-PICARDIE %~ AGIR-UPJV %~ INFECTIOLOGIE-SANTE-PUBLIQUE %~ MICA-UNITES %~ INRAEVALDELOIRE %~ NANTES-UNIVERSITE %~ UNIV-NANTES-AV2022 %~ RESEAU-EAU %~ UFR-MEDECINE-NANTES