%0 Journal Article %T Squamous Cell Carcinoma Antigen-encoding Genes SERPINB3/B4 as Potentially Useful Markers for the Stratification of HNSCC Tumours %+ CHirurgie, IMagerie et REgénération tissulaire de l’extrémité céphalique - Caractérisation morphologique et fonctionnelle - UR UPJV 7516 (CHIMERE) %+ CHU Amiens-Picardie %+ HEMATIM - Hématopoïèse et immunologie - UR UPJV 4666 (HEMATIM) %+ Université de Picardie Jules Verne (UPJV) %A Saidak, Zuzana %A Morisse, Mony Chenda %A Chatelain, Denis %A Sauzay, Chloé %A Houessinon, Aline %A Guilain, Nelly %A Soyez, Marion %A Chauffert, Bruno %A Dakpé, Stéphanie %A Galmiche, Antoine %< avec comité de lecture %@ 0250-7005 %J Anticancer Research %I International Institute of Anticancer Research %V 38 %N 3 %P 1343-1352 %8 2018 %D 2018 %R 10.21873/anticanres.12357 %Z Life Sciences [q-bio]Journal articles %X Background/Aim: The squamous cell carcinoma antigen (SCCA), encoded by the genes SERPINB3/B4, is a tumour marker produced by head and neck squamous cell carcinoma (HNSCC). We aimed to examine SERPINB3/B4 mRNA levels and its clinical significance in the therapeutic context. Materials and Methods: We retrieved mRNA expression levels, clinical, pathological and genomic data for 520 HNSCC from The Cancer Genome Atlas (TCGA). Results: HNSCC tumours express high levels of SERPINB3/B4 mRNA. SERPINB3 expression differs depending on Human papillomavirus (HPV) infection status, primary tumour location, grade and differentiation, extension to lymph nodes and extracapsular spread. Interestingly, we observed an association between SERPINB3/B4 and the presence of tumour immune infiltrate as well as the expression of the immune checkpoint regulators PDL1/PD-L2 that depended on HPV status. Conclusion: Our findings point to potential interest of SERPINB3/B4 for the stratification of HNSCC patients in the therapeutic context. %G English %L hal-03598676 %U https://u-picardie.hal.science/hal-03598676 %~ UNIV-PICARDIE %~ U-PICARDIE %~ CHIMERE %~ HEMATIM