%0 Journal Article %T Episodic headache with spontaneous hypothermia reveal Shapiro's syndrome variant with effectiveness of clonidine therapy %+ Laboratoire de Neurosciences Fonctionnelles et Pathologies - UR UPJV 4559 (LNFP) %+ Noyaux gris centraux %+ Service de neurologie [Amiens] %A Aubignat, Mickael %A Tir, Melissa %A Krystkowiak, Pierre %A Andriuta, Daniela %< avec comité de lecture %@ 1129-2369 %J Journal of Headache and Pain %I SpringerOpen %V 22 %N 1 %8 2021 %D 2021 %R 10.1186/s10194-021-01245-3 %Z Life Sciences [q-bio]Journal articles %X Background Episodic headache with spontaneous hypothermia constitute an uncommon association and is not well recognized in the International Classification of Headache Disorders (ICHD-3). Spontaneous periodic hypothermia, also called Shapiro's syndrome, is a rare disease characterized by hypothermia attacks associated or not with hyperhidrosis without any triggering factor. Case presentation We report a rare case of Shapiro's syndrome variantrevealed by episodes of headache with spontaneous hypothermia witheffectiveness of clonidine therapy in a 76-year-old Parkinson's disease woman. Conclusions In the literature, apart from Shapiro's syndrome, headache withhypothermia seem to occur very rarely. In our case,these symptoms may be considered as a very rare non-motor fluctuation ofParkinson's disease. %G English %L hal-03606959 %U https://u-picardie.hal.science/hal-03606959 %~ UNIV-PICARDIE %~ U-PICARDIE %~ LNFP