%0 Journal Article %T Characteristics, Management, and Outcomes of Patients with Multiple Native Valvular Heart Disease: A Substudy of the EURObservational Research Programme Valvular Heart Disease II Survey. %+ Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV) %+ CHU Amiens-Picardie %+ University hospital of Zurich [Zurich] %+ University of Medicine and Pharmacy “Carol Davila” Bucharest (UMPCD) %+ King's College Hospital (KCH) %+ EURObservational Research Programme, European Society of Cardiology %+ Semmelweis University [Budapest] %+ University Medical Center Rostock %+ Slovak Medical University of Bratislava (SMU) %+ Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)) %+ AP-HP - Hôpital Bichat - Claude Bernard [Paris] %A Tribouilloy, Christophe %A Bohbot, Yohann %A Kubala, Maciej %A Ruschitzka, Frank %A Popescu, Bogdan %A Wendler, Olaf %A Laroche, Cécile %A Bartha, Elektra %A Ince, Huseyin %A Simkova, Iveta %A Vahanian, Alec %A Iung, Bernard %Z Erratum inCorrigendum to: Characteristics, management, and outcomes of patients with multiple native valvular heart disease: a substudy of the EURObservational Research Programme Valvular Heart Disease II Survey. Eur Heart J. 2022 Aug 1;43(29):2813. doi: 10.1093/eurheartj/ehac341.PMID: 35716135 %< avec comité de lecture %@ 0195-668X %J European Heart Journal %I Oxford University Press (OUP) %V 43 %N 29 %P 2756--2766 %8 2022 %D 2022 %R 10.1093/eurheartj/ehac209 %M 35511056 %K *Heart Failure/complications/epidemiology/therapy %K *Heart Valve Diseases/surgery %K Cardiac surgery %K Female %K Hospitalization %K Humans %K Management %K Multiple valvular heart disease %K Native valvular heart disease %K Survival %K Valvular Heart Disease II Survey %Z Life Sciences [q-bio]/Human health and pathologyJournal articles %X AIMS: To assess the characteristics, management, and survival of patients with multiple native valvular heart disease (VHD). METHODS AND RESULTS: Among the 5087 patients with ≥q1 severe left-sided native VHD included in the EURObservational VHD II Survey (maximum 3-month recruitment period per centre between January and August 2017 with a 6-month follow-up), 3571 had a single left-sided VHD (Group A, 70.2%), 363 had one severe left-sided VHD with moderate VHD of the other ipsilateral valve (Group B, 7.1%), and 1153 patients (22.7%) had ≥q2 severe native VHDs (left-sided and/or tricuspid regurgitation, Group C). Patients with multiple VHD (Groups B and C) were more often women, had greater congestive heart failure (CHF) and comorbidity, higher left atrial volumes and pulmonary pressures, and lower ejection fraction than Group A patients (all P\,≤q\,0.01). During the index hospitalization, 36.7% of Group A (n\,=\,1312), 26.7% of Group B (n\,=\,97), and 32.7% of Group C (n\,=\,377) underwent valvular intervention (P\,<\,0.001). Six-month survival was better for Group A than for Group B or C (both P\,<\,0.001), even after adjustment for age, sex, body mass index, and Charlson index [hazard ratio (HR) 95% confidence interval (CI) 1.62 (1.10-2.38) vs. Group B and HR 95% CI 1.72 (1.32-2.25) vs. Group C]. Groups B and C had more CHF at 6 months than Group A (both P\,<\,0.001). Factors associated with mortality in Group C were age, CHF, and comorbidity (all P\,<\,0.010). CONCLUSION: Multiple VHD is common, encountered in nearly 30% of patients with left-sided native VHD, and associated with greater cardiac damage and leads to higher mortality and more heart failure at 6 months than single VHD, yet with lower rates of surgery. %G English %L hal-03746088 %U https://u-picardie.hal.science/hal-03746088 %~ INSERM %~ UNIV-PARIS13 %~ UNIV-PICARDIE %~ APHP %~ SORBONNE-PARIS-NORD %~ UNIV-PARIS %~ UNIVERSITE-PARIS %~ UP-SANTE %~ U-PICARDIE %~ MP3CV %~ TEST3-HALCNRS