%0 Journal Article %T Incidence and Characteristics of Pseudoprogression in IDH-mutant High-Grade Gliomas: A POLA Network Study. %+ Hospices Civils de Lyon, Departement de Neurologie (HCL) %+ Institut du Cerveau = Paris Brain Institute (ICM) %+ CHU Pitié-Salpêtrière [AP-HP] %+ Institut de neurophysiopathologie (INP) %+ Hôpital de la Timone [CHU - APHM] (TIMONE) %+ CHU Bordeaux [Bordeaux] %+ Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO) %+ Service de Neurochirurgie [CHU Caen] %+ Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity) %+ CHU Amiens-Picardie %+ CHirurgie, IMagerie et REgénération tissulaire de l’extrémité céphalique - Caractérisation morphologique et fonctionnelle - UR UPJV 7516 (CHIMERE) %+ Chemistry, Oncogenesis, Stress and Signaling (COSS) %+ CRLCC Eugène Marquis (CRLCC) %+ Culture et Environnements, Préhistoire, Antiquité, Moyen-Age (CEPAM) %+ Service de neurochirurgie [Brest] %+ Laboratoire de Traitement de l'Information Medicale (LaTIM) %+ Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] (UNICANCER/CAL) %+ Hospices Civils de Lyon (HCL) %+ Institut NeuroMyoGène (INMG) %+ Centre de Référence Maladie Rare "Syndromes neurologiques Paranéoplasiques" %+ Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL] %A Seyve, Antoine %A Dehais, Caroline %A Chinot, Olivier %A Djelad, Apolline %A Cohen-Moyal, Elisabeth %A Bronnimann, Charlotte %A Gourmelon, Carole %A Emery, Evelyne %A Colin, Philippe %A Boone, Mathieu %A Vauléon, Elodie %A Langlois, Olivier %A Stefano, Anna-Luisa, Di %A Seizeur, Romuald %A Ghiringhelli, François %A d'Hombres, Anne %A Feuvret, Loic %A Guyotat, Jacques %A Capelle, Laurent %A Carpentier, Catherine %A Garnier, Louis %A Honnorat, Jérôme %A Meyronet, David %A Mokhtari, Karima %A Figarella-Branger, Dominique %A Ducray, François %< avec comité de lecture %@ 1522-8517 %J Neuro-Oncology %I Oxford University Press (OUP) %V 25 %N 3 %P 495-507 %8 2023-03-14 %D 2023 %R 10.1093/neuonc/noac194 %M 35953421 %K chemotherapy %K High-grade glioma %K IDH-mutant %K pseudoprogression %K radiotherapy %Z Life Sciences [q-bio]/Human health and pathologyJournal articles %X BACKGROUND: Incidence and characteristics of pseudoprogression in isocitrate dehydrogenase-mutant high-grade gliomas (IDHmt HGG) remain to be specifically described. METHODS: We analyzed pseudoprogression characteristics and explored the possibility of pseudoprogression misdiagnosis in IDHmt HGG patients, treated with radiotherapy (with or without chemotherapy), included in the French POLA network. Pseudoprogression was analyzed in patients with MRI available for review (reference cohort, n=200). Pseudoprogression misdiagnosis was estimated in this cohort and in an independent cohort (control cohort, n=543) based on progression free survival before and after first progression. RESULTS: In the reference cohort, 38 patients (19%) presented a pseudoprogression after a median time of 10.5 months after radiotherapy. Pseudoprogression characteristics were similar across IDHmt HGG subtypes. In most patients, it consisted in the appearance of one or several infracentimetric, asymptomatic, contrast-enhanced lesions occurring within 2 years after radiotherapy. The only factor associated with pseudoprogression occurrence was adjuvant PCV chemotherapy. Among patients considered as having a first true progression, 7 out of 41 (17%) in the reference cohort and 35 out of 203 (17%) in the control cohort were retrospectively suspected to have a misdiagnosed pseudoprogression. Patients with a misdiagnosed pseudoprogression were characterized by a time to event and an outcome similar to that of patients with a pseudoprogression but presented with larger and more symptomatic lesions. CONCLUSION: In patients with an IDHmt HGG, pseudoprogression occurs later than in IDH-wildtype glioblastomas and seems not only frequent but also frequently misdiagnosed. Within the first 2 years after radiotherapy, the possibility of a pseudoprogression should be carefully considered. %G English %L hal-03753737 %U https://u-picardie.hal.science/hal-03753737 %~ UNICE %~ UNIV-BREST %~ INSTITUT-TELECOM %~ HCL %~ UNIV-TLSE3 %~ UNIV-RENNES1 %~ CNRS %~ UNIV-AMU %~ UNIV-PICARDIE %~ UNIV-LYON1 %~ APHP %~ CEPAM %~ FNCLCC %~ LACASSAGNE %~ MARQUIS %~ ICO %~ ICM %~ OSS %~ COMUE-NORMANDIE %~ UR1-UFR-SVE %~ UR1-HAL %~ UR1-SDV %~ UNIV-COTEDAZUR %~ INP %~ TEST-UR-CSS %~ UNIV-RENNES %~ UNICAEN %~ LATIM %~ SORBONNE-UNIVERSITE %~ SORBONNE-UNIV %~ IBSAM %~ SU-MEDECINE %~ SU-MED %~ UDL %~ UNIV-LYON %~ INSTITUTS-TELECOM %~ UR1-BIO-SA %~ INFINITY %~ U-PICARDIE %~ CHIMERE %~ NEUROMARSEILLE %~ ALLIANCE-SU %~ UNIV-UT3 %~ UT3-INP %~ UT3-TOULOUSEINP %~ TEST3-HALCNRS %~ TEST4-HALCNRS %~ TEST5-HALCNRS