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                <term xml:lang="en">ulcerative colitis</term>
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                <term xml:lang="en">switch</term>
                <term xml:lang="en">subcutaneous</term>
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              <p>BACKGROUND AND AIM: We assessed the effectiveness of switching from intravenous to subcutaneous infliximab in patients with inflammatory bowel diseases (IBD) treated with or without intensified intravenous regimen. METHODS: In this multicenter observational study, IBD patients in clinical remission (partial Mayo score ≤q 2 or Harvey-Bradshaw index ≤q 4) were switched to a unique dose of subcutaneous infliximab (120 mg eow). Pharmacological and biological data were collected at baseline, visit 1 (4-8 weeks post-switch), visit 2 (8-16 weeks post-switch) and visit 3 (16-24 weeks post-switch). Relapse was defined as clinical relapse or faecal calprotectin increase ≥q 150 μg/g compared to baseline. RESULTS: Among 184 eligible patients, 72.3% (133/184) agreed to switch to subcutaneous infliximab. At visit 3, a relapse occurred in 10.2% (6/59), 7.3% (3/38), 16.7% (3/18) and 66.7% (10/15) (p &lt; 0.001) of patients receiving 5mg/kg/8weeks, 10 mg/kg/8weeks, 10mg/kg/6weeks, and 10mg/kg/4weeks, respectively. Dose escalation to 240mg eow, led to recapture clinical remission in 93.3% (14/15). Infliximab serum levels increased after the switch (p&lt;0.0001) except for patients receiving 10 mg/kg/4 weeks. In multivariable analysis, 10mg/kg/4 weeks regimen (OR=12.4[1.6-98.4], p=0.017) and faecal calprotectin &gt;250 μg/g at baseline (OR=5.4[1.1-27.6],p=0.042) had a higher risk of relapse as well as reduced (41.7%) or stable (36.8%) infliximab serum levels between baseline and visit 1 compared to increased serum levels (12.7%) (p=0.020 and p=0.019, respectively). Patients' acceptability (10 points-scale) was improved by the switch (6.9±1.6 vs 8.6±1.4; p&lt;0.0001). No severe adverse event was reported. CONCLUSIONS: Switching from intravenous to subcutaneous infliximab 120 mg eow is safe and well-accepted leading to a low risk of relapse in IBD patients except for those receiving 10mg/kg/4weeks requiring 240 mg eow.</p>
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