%0 Journal Article %T No Impact of Corticosteroid Use During the Acute Phase on Persistent Symptoms Post-COVID-19 %+ Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV) %+ CHU Amiens-Picardie %+ Thèses d'exercice et mémoires - UFR de Médecine Montpellier-Nîmes %+ Agents infectieux, résistance et chimiothérapie - UR UPJV 4294 (AGIR ) %+ Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U 1192 (PRISM) %A Ko, Adrien Chan Sui %A Candellier, Alexandre %A Mercier, Marie %A Joseph, Cedric %A Carette, Hortense %A Basille, Damien %A Lion-Daolio, Sylvie %A Devaux, Stephanie %A Schmit, Jean-Luc %A Lanoix, Jean-Philippe %A Andrejak, Claire %< avec comité de lecture %J International Journal of General Medicine %I Dove Press ; Taylor & Francis %V 15 %P 6645-6651 %8 2022 %D 2022 %R 10.2147/IJGM.S367273 %K COVID-19 %K persistent symptoms %K corticosteroid use %K long COVID-19 %K asthenia %Z Life Sciences [q-bio]/Human health and pathologyJournal articles %X Persistent COVID-19 symptoms may be related to residual inflammation, but no preventive treatment has been evaluated. This study aimed to analyze, in a prospective cohort, whether corticosteroid use in the acute phase of COVID-19 in hospitalized patients may reduce the risk of persistent COVID-19 symptoms. A total of 306 discharged patients, including 112 (36.6%) from the ICU, completed a structured face-to-face assessment 4 months after admission. Of these, 193 patients (63.1%) had at least one persistent symptom, mostly dyspnea (38.9%) and asthenia (37.6%). One-hundred and four patients have received corticosteroids. In multivariable adjusted regression analysis, corticosteroid use was not associated with the presence of at least one symptom (OR=1.00, 95% CI: 0.58-1.71, p=0.99) or with the number of persistent symptoms (p=0.74). Corticosteroid use remained ineffective when analyzing the ICU subpopulation separately. Our study suggests that corticosteroid use had no impact on persistent symptoms after COVID-19 in discharged patients. %G English %L hal-03767758 %U https://u-picardie.hal.science/hal-03767758 %~ UNIV-PICARDIE %~ UNIV-MONTPELLIER %~ UNIV-LILLE %~ U-PICARDIE %~ MP3CV %~ AGIR-UPJV %~ UM-2015-2021