%0 Journal Article %T Personality Assessment with Temperament and Character Inventory in Parkinson's Disease. %+ Toulouse Neuro Imaging Center (ToNIC) %+ Centre Hospitalier Universitaire de Toulouse (CHU Toulouse) %+ Centre Hospitalier de Brive-la-Gaillarde (CH Brive) %+ Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL) %+ Université Claude Bernard Lyon 1 (UCBL) %+ Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL] %+ Hospices Civils de Lyon (HCL) %+ CHU Marseille %+ CHU Pitié-Salpêtrière [AP-HP] %+ Sorbonne Université - Faculté de Médecine (SU FM) %+ Institut du Cerveau = Paris Brain Institute (ICM) %+ Hôpital de la Fondation Ophtalmologique Adolphe de Rothschild [AP-HP] %+ Centre d’Excellence en Maladies Neurodégénératives (NeuroToul) %+ CIC - Biotherapie - Toulouse %+ Lille Neurosciences & Cognition - U 1172 (LilNCog) %+ CHU Lille %+ Service NEUROSPIN (NEUROSPIN) %+ Hôpital Foch [Suresnes] %+ Neuroimagerie cognitive - Psychologie cognitive expérimentale (UNICOG-U992) %+ Différenciation et communication neuronale et neuroendocrine (DC2N) %+ CHU Rouen %+ Centre d'Investigation Clinique [Rennes] (CIC) %+ CHU Pontchaillou [Rennes] %+ Institut national polytechnique Clermont Auvergne (INP Clermont Auvergne) %+ Institut Pascal (IP) %+ CHU Bordeaux [Bordeaux] %+ Les Hôpitaux Universitaires de Strasbourg (HUS) %+ Fédération de Médecine Translationnelle de Strasbourg (FMTS) %+ Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC) %+ Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy) %+ Centre Hospitalier Universitaire de Nice (CHU Nice) %+ CHU Amiens-Picardie %+ Laboratoire de Neurosciences Fonctionnelles et Pathologies - UR UPJV 4559 (LNFP) %+ Centre hospitalier universitaire de Nantes (CHU Nantes) %A Boussac, Mathilde %A Arbus, Christophe %A Colin, Olivier %A Laurencin, Chloé %A Eusebio, Alexandre %A Hainque, Elodie %A Corvol, Jean Christophe %A Versace, Nathalie %A Rascol, Olivier %A Rousseau, Vanessa %A Harroch, Estelle %A Ory-Magne, Fabienne %A Fabbri, Margherita %A Moreau, Caroline %A Rolland, Anne-Sophie %A Jarraya, Béchir %A Maltête, David %A Drapier, Sophie %A Marques, Ana-Raquel %A Auzou, Nicolas %A Wirth, Thomas %A Meyer, Mylène %A Giordana, Bruno %A Tir, Mélissa %A Rouaud, Tiphaine %A Devos, David %A Brefel-Courbon, Christine %Z This work was supported by the France Parkinson charity and French Ministry of Health (PHRC national 2012). This is an ancillary study to Protocol ID: 2013-A00193-42; ClinicalTrials.gov: NCT02360683. %< avec comité de lecture %@ 1353-8020 %J Parkinsonism & Related Disorders %I Elsevier %V 103 %P 34--41 %8 2022-08-18 %D 2022 %R 10.1016/j.parkreldis.2022.08.004 %M 36030666 %K Fluctuating PD patients %K Parkinson's disease %K Personality %K Temperament and character inventory %Z Life Sciences [q-bio]/Human health and pathologyJournal articles %X INTRODUCTION: There is a growing interest in personality evaluation in Parkinson's disease (PD), following observations of specific temperaments in PD patients. Therefore, our objective was to evaluate personality dimensions from the Temperament and Character Inventory (TCI) in a cohort of fluctuating PD patients considered for deep brain stimulation. METHODS: Fluctuating PD patients from the PREDISTIM cohort were included. Description of TCI dimensions and comparison with a French normative cohort were performed. Pearson correlations between TCI dimensions and motor, behavioral and cognitive variables were investigated. Structural and internal consistency analysis of the TCI were further assessed. RESULTS: The 570 PD patients presented significant higher scores in Harm Avoidance, Reward Dependence, Persistence, Self-Directedness and Cooperativeness and significant lower scores in Self-Transcendence compared to the French normative cohort; only Novelty Seeking scores were not different. Harm Avoidance and Self-directedness scores were correlated with PDQ-39 total, HAMD, HAMA scores, and anxiolytic/antidepressant treatment. Novelty Seeking scores were correlated with impulsivity. Pearson correlations between TCI dimensions, principal component analysis of TCI sub-dimensions and Cronbach's alpha coefficients showed adequate psychometric proprieties. CONCLUSION: The TCI seems to be an adequate tool to evaluate personality dimensions in PD with good structural and internal consistencies. These fluctuating PD patients also have specific personality dimensions compared to normative French population. Moreover, Harm Avoidance and Self-Directedness scores are associated with anxio-depressive state or quality of life and, and Novelty Seeking scores with impulsivity. %G English %2 https://u-picardie.hal.science/hal-03767971/document %2 https://u-picardie.hal.science/hal-03767971/file/Revised%20Manuscript2_HAL%20%281%29.PDF %L hal-03767971 %U https://u-picardie.hal.science/hal-03767971 %~ UNIV-ST-ETIENNE %~ CEA %~ HCL %~ UNIV-TLSE2 %~ UNIV-TLSE3 %~ UNIV-RENNES1 %~ PRES_CLERMONT %~ CNRS %~ UNIV-PICARDIE %~ UNIV-BPCLERMONT %~ UNIV-LYON1 %~ IGBMC %~ APHP %~ UNIV-STRASBG %~ INSTITUT_PASCAL %~ HL %~ CIC %~ CIC203 %~ ICM %~ COMUE-NORMANDIE %~ ACL-SVSAE %~ CEA-UPSAY %~ UR1-UFR-SVE %~ UR1-HAL %~ UR1-SDV %~ UNIV-PARIS-SACLAY %~ JOLIOT %~ CEA-DRF %~ NEUROSPIN %~ TEST-UR-CSS %~ SITE-ALSACE %~ UNIV-RENNES %~ UNIROUEN %~ UNIV-LILLE %~ DC2N %~ SORBONNE-UNIVERSITE %~ SORBONNE-UNIV %~ SU-MEDECINE %~ SU-MED %~ UDL %~ UNIV-LYON %~ UNIVERSITE-PARIS-SACLAY %~ SU-TI %~ UR1-BIO-SA %~ GS-ENGINEERING %~ GS-LIFE-SCIENCES-HEALTH %~ U-PICARDIE %~ LNFP %~ CLERMONT-AUVERGNE-INP %~ ALLIANCE-SU %~ CRNL %~ UNIV-UT3 %~ UT3-INP %~ UT3-TOULOUSEINP %~ TONIC