%0 Journal Article %T Early Improvement of Neuropsychological Impairments During Detoxification in Patients with Alcohol Use Disorder. %+ Groupe de Recherche sur l'alcool et les pharmacodépendances - UMR INSERM_S 1247 (GRAP) %+ Laboratoire de psychologie de Caen Normandie (LPCN) %+ Neuropsychologie et imagerie de la mémoire humaine (NIMH) %A Angerville, Bernard %A Ritz, Ludivine %A Pitel, Anne Lise %A Beaunieux, Hélène %A Houchi, Hakim %A Martinetti, Margaret P. %A Naassila, Mickaël %A Dervaux, Alain %< avec comité de lecture %@ 0735-0414 %J Alcohol and Alcoholism %I Oxford University Press (OUP) %P agac048 %8 2022 %D 2022 %R 10.1093/alcalc/agac048 %M 36221321 %Z Life Sciences [q-bio]/Human health and pathologyJournal articles %X AIMS: To assess recovery of alcohol-related neuropsychological deficits in a group of patients with pure severe alcohol use disorder (AUD) during a detoxification program using the Brief Evaluation of Alcohol-Related Neuropsychological Impairment (BEARNI) test. METHODS: Thirty-two patients with severe AUD using DSM-IV criteria (24 men, mean age\,=\,45.5\,±\,6.8~years old) were assessed using the BEARNI 8\,±\,2~days after alcohol cessation (T1) and then were reassessed within 18\,±\,2~days after alcohol cessation (T2). The primary study endpoint was the number of patients initially impaired at T1 who recovered cognitive functions at T2 assessment. RESULTS: At T1, 59% (n\,=\,19) patients with pure severe AUD had at least one impaired cognitive function assessed by the BEARNI. At T2, 63% of the patients with AUD with deficits at T1 had normal BEARNI cognitive scores (χ2\,=\,7.7, P\,=\,0.005); specifically, the percentages of participants with normal subtest scores were 63% on memory (χ2\,=\,12.4, P\,=\,0.0004), 100% on verbal fluency (χ2\,=\,16; P\,=\,<0.0001), 60% on alphabetical span (χ2\,=\,12.8; P\,=\,0.0003) and 67% on visuospatial (χ2\,=\,15, P\,=\,0.0001). CONCLUSIONS: The cognitive impairments of two-thirds of patients with pure AUD included in the present study recovered within 18~days of abstinence, earlier than reported in previous studies. %G English %L hal-03814208 %U https://u-picardie.hal.science/hal-03814208 %~ EPHE %~ UNIV-PICARDIE %~ COMUE-NORMANDIE %~ PSL %~ UNICAEN %~ NIMH %~ TEST-DEV %~ LPCN %~ EPHE-PSL %~ U-PICARDIE %~ GRAP %~ TEST3-HALCNRS