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Article Dans Une Revue Current Medicinal Chemistry Année : 2020

Marine Natural Products with High Anticancer Activities

Dario Matulja
  • Fonction : Auteur
Karlo Wittine
  • Fonction : Auteur
Nela Malatesti
  • Fonction : Auteur
Maris Turks
  • Fonction : Auteur
Maria Kolympadi Markovic
  • Fonction : Auteur
Gabriela Ambrožić
  • Fonction : Auteur
Dean Marković
  • Fonction : Auteur


This review covers recent literature from 2012-2019 concerning 170 marine natural products and their semisynthetic analogues with strong anticancer biological activities. Reports that shed light on cellular and molecular mechanisms and biological functions of these compounds, thus advancing the understanding in cancer biology are also included. Biosynthetic studies and total syntheses, which have provided access to derivatives and have contributed to the proper structure or stereochemistry elucidation or revision are mentioned. The natural compounds isolated from marine organisms are divided into nine groups, namely: alkaloids, sterols and steroids, glycosides, terpenes and terpenoids, macrolides, polypeptides, quinones, phenols and polyphenols, and miscellaneous products. An emphasis is placed on several drugs originating from marine natural products that have already been marketed or are currently in clinical trials.
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Dates et versions

hal-03832648 , version 1 (27-10-2022)



Dario Matulja, Karlo Wittine, Nela Malatesti, Sylvain Laclef, Maris Turks, et al.. Marine Natural Products with High Anticancer Activities. Current Medicinal Chemistry, 2020, 27 (8), pp.1243-1307. ⟨10.2174/0929867327666200113154115⟩. ⟨hal-03832648⟩
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