%0 Journal Article %T Trends of use and factors that determine the choice of oral anticoagulants in women and men with atrial fibrillation %+ Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV) %+ CHU Amiens-Picardie %A Lenglet, Aurélie %A Qazi, Jakub %A Boivin Proulx, Laurie‐anne %A Legault, Catherine %A Dorais, Marc %A Perreault, Sylvie %J Pharmacology Research & Perspectives %I Wiley %V 10 %N 6 %8 2022-12 %D 2022 %R 10.1002/prp2.1012 %K anticoagulants %K atrial fibrillation %K oral administration %K pharmacoepidemiology %K prescription drugs %Z Life Sciences [q-bio]/Human health and pathologyJournal articles %X The aim was to identify sex-specific factors linked with oral anticoagulant initiation in a cohort of patients with atrial fibrillation using administrative data from Quebec (Canada) between 2014 and 2017. Cohort entry defined as new users, that is, no claims in last 12 months, a cohort of 32 050 patients was stratified in two groups, that is, women and men. Multivariable regression models were used to identify factors of initiations for low- and standard-dose direct oral anticoagulants (DOACs) versus warfarin, and low- versus standard-dose DOACs. In both sexes, warfarin initiation decreased and DOAC initiation increased, with year of initiation as major factors of DOACs use. In 2017, the increase was of 2- to 4-fold and 3- to 8-fold for low- and standard-dose DOACs (vs. warfarin), respectively. The proportion of patients starting on a low-dose DOAC was higher in women than men. Older age for both sexes and CHADS2 score ≥2 (only women) were major factors of low-dose dabigatran and rivaroxaban versus warfarin use. The only significant factor of standard-dose DOAC versus warfarin use was age of 65-79 for women or men treated with apixaban by 1.8- and 1.4-fold, respectively. Factors that made women and men less likely to receive a standard-dose DOAC versus warfarin were higher CHADS2 (for dabigatran and rivaroxaban), HAS-BLED and frailty scores, prior coronary disease, major bleeding, and chronic kidney disease (CKD) status. The choice of a low- versus standard-dose DOAC was mainly driven by age and CKD, and higher CHADS2 score (for dabigatran and apixaban) for both sexes. %G English %L hal-03870121 %U https://u-picardie.hal.science/hal-03870121 %~ UNIV-PICARDIE %~ U-PICARDIE %~ MP3CV