%0 Journal Article %T Preictal neuronal and vascular activity precedes the onset of childhood absence seizure: direct current potential shifts and their correlation with hemodynamic activity %+ Groupe de Recherche sur l'Analyse Multimodale de la Fonction Cérébrale - UMR INSERM_S 1105 (GRAMFC) %+ CHU Amiens-Picardie %A Nourhashemi, Mina %A Mahmoudzadeh, Mahdi %A Heberle, Claire %A Wallois, Fabrice %@ 2329-423X %J Neurophotonics %I Society of Photo-optical Instrumentation Engineers (SPIE) %V 10 %N 02 %8 2023-04-01 %D 2023 %R 10.1117/1.NPh.10.2.025005 %K absence epilepsy %K cerebral blood flow %K cerebral hemodynamics %K diffuse correlation spectroscopy %K direct current potential %K electroencephalography %K functional near-infrared spectroscopy %K general spike and wave discharges %K seizure %Z Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]Journal articles %X Significance aims: The neurovascular mechanisms underlying the initiation of absence seizures and their dynamics are still not well understood. The objective of this study was to better noninvasively characterize the dynamics of the neuronal and vascular network at the transition from the interictal state to the ictal state of absence seizures and back to the interictal state using a combined electroencephalography (EEG), functional near-infrared spectroscopy (fNIRS), and diffuse correlation spectroscopy (DCS) approach. The second objective was to develop hypotheses about the neuronal and vascular mechanisms that propel the networks to the 3-Hz spikes and wave discharges (SWDs) observed during absence seizures.Approaches: We evaluated the simultaneous changes in electrical (neuronal) and optical dynamics [hemodynamic, with changes in (Hb) and cerebral blood flow] of 8 pediatric patients experiencing 25 typical childhood absence seizures during the transition from the interictal state to the absence seizure by simultaneously performing EEG, fNIRS, and DCS.Results: Starting from ∼20sbefore the onset of the SWD, we observed a transient direct current potential shift that correlated with alterations in functional fNIRS and DCS measurements of the cerebral hemodynamics detecting the preictal changes.Discussion: Our noninvasive multimodal approach highlights the dynamic interactions between the neuronal and vascular compartments that take place in the neuronal network near the time of the onset of absence seizures in a very specific cerebral hemodynamic environment. These noninvasive approaches contribute to a better understanding of the electrical hemodynamic environment prior to seizure onset. Whether this may ultimately be relevant for diagnostic and therapeutic approaches requires further evaluation. %G English %L hal-04089042 %U https://u-picardie.hal.science/hal-04089042 %~ UNIV-PICARDIE %~ U-PICARDIE %~ GRAMFC