Epidemiology and Dynamics of BK Polyomavirus Replication after Kidney Transplantation - Université de Picardie Jules Verne
Article Dans Une Revue Pathogens Année : 2024

Epidemiology and Dynamics of BK Polyomavirus Replication after Kidney Transplantation

Résumé

Background/Objectives: In the absence of an effective antiviral treatment for BK polyomavirus (BKPyV), a better understanding of the epidemiology and time course of BKPyV replication after kidney transplantation is needed to limit the virus’s impact on the graft outcome. Methods: In a 7-year study, we screened more than 430 kidney transplant recipients and analyzed the time course and virological characteristics of BKPyV replication. Results: Urinary viral replication was observed in 116 (27%) of the 430 patients, and 90 of the 116 (78%) had viral DNAemia. Thirty-eight patients (8.8%) were presumed to have nephropathy (DNAemia > 4 log10 copies/mL). Of the patients with BKPyV replication, 48%, 60%, 71%, and 80% were first found to be positive one, two, three, and four months post-transplantation. The initial viral load in the urine was below 7 log10 copies/mL in 100% of the patients with viral replication first detected before the first month, and this proportion was 57% when viral replication was first detected after the first month. When the BKPyV replication was first detected in a urine sample at month 3 or later, 81.5% of patients had concomitant BKPyV DNAemia. The predominant viral subtype was Ib2 (60%), and there was no apparent relationship between the subtype and the time course of BKPyV replication. Conclusions: Urinary BKPyV replication occurs early after renal transplantation and in most patients will increase to a level requiring therapeutic intervention. Close monitoring for BKPyV in the early post-transplantation period would enable the pre-emptive adjustment of the immunosuppression regimen.
Fichier principal
Vignette du fichier
main.pdf (2.02 Mo) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-04566613 , version 1 (15-12-2024)

Identifiants

Citer

Etienne Brochot, Baptiste Demey, Aurélien Aubry, Véronique Descamps, Virginie Morel, et al.. Epidemiology and Dynamics of BK Polyomavirus Replication after Kidney Transplantation. Pathogens, 2024, 13 (4), pp.315. ⟨10.3390/pathogens13040315⟩. ⟨hal-04566613⟩
18 Consultations
0 Téléchargements

Altmetric

Partager

More