<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-04633156</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-12T04:54:20+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Discovery of BI-9508, a Brain-Penetrant GPR88-Receptor-Agonist Tool Compound for In Vivo Mouse Studies</title>
            <author role="aut">
              <persName>
                <forename type="first">Mickael</forename>
                <surname>Fer</surname>
              </persName>
              <idno type="halauthorid">3187288-0</idno>
              <affiliation ref="#struct-1776601"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Camille</forename>
                <surname>Amalric</surname>
              </persName>
              <idno type="halauthorid">250749-0</idno>
              <affiliation ref="#struct-1776601"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Roberto</forename>
                <surname>Arban</surname>
              </persName>
              <idno type="halauthorid">3187289-0</idno>
              <affiliation ref="#struct-467084"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Luc</forename>
                <surname>Baron</surname>
              </persName>
              <idno type="halauthorid">1168107-0</idno>
              <affiliation ref="#struct-1776601"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sami</forename>
                <surname>Ben Hamida</surname>
              </persName>
              <email type="md5">61b3ab409d17245f9bffae16a08947f5</email>
              <email type="domain">u-picardie.fr</email>
              <idno type="idhal" notation="string">sami-ben-hamida</idno>
              <idno type="idhal" notation="numeric">1082082</idno>
              <idno type="halauthorid" notation="string">697238-1082082</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-9636-9432</idno>
              <idno type="IDREF">https://www.idref.fr/151197873</idno>
              <affiliation ref="#struct-580112"/>
              <affiliation ref="#struct-134741"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Petra</forename>
                <surname>Breh-Schlanser</surname>
              </persName>
              <idno type="halauthorid">3187290-0</idno>
              <affiliation ref="#struct-467084"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Yunhai</forename>
                <surname>Cui</surname>
              </persName>
              <idno type="idhal" notation="numeric">1397289</idno>
              <idno type="halauthorid" notation="string">3187291-1397289</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-4969-072X</idno>
              <affiliation ref="#struct-467084"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Emmanuel</forename>
                <surname>Darcq</surname>
              </persName>
              <email type="md5">c25420680a259ea445e261320d5d94e5</email>
              <email type="domain">unistra.fr</email>
              <idno type="idhal" notation="string">emmanuel-darcq</idno>
              <idno type="idhal" notation="numeric">769181</idno>
              <idno type="halauthorid" notation="string">731570-769181</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-8377-8015</idno>
              <affiliation ref="#struct-508848"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Christian</forename>
                <surname>Eickmeier</surname>
              </persName>
              <idno type="halauthorid">3187292-0</idno>
              <affiliation ref="#struct-467084"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Vincent</forename>
                <surname>Faye</surname>
              </persName>
              <idno type="halauthorid">3187293-0</idno>
              <affiliation ref="#struct-1776601"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Christel</forename>
                <surname>Franchet</surname>
              </persName>
              <idno type="halauthorid">345394-0</idno>
              <affiliation ref="#struct-1776601"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Mélanie</forename>
                <surname>Frauli</surname>
              </persName>
              <idno type="halauthorid">350105-0</idno>
              <affiliation ref="#struct-1776601"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Célia</forename>
                <surname>Halter</surname>
              </persName>
              <idno type="halauthorid">3187294-0</idno>
              <affiliation ref="#struct-1776601"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marjorie</forename>
                <surname>Heyer</surname>
              </persName>
              <idno type="halauthorid">3187295-0</idno>
              <affiliation ref="#struct-1776601"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Christoph</forename>
                <surname>Hoenke</surname>
              </persName>
              <idno type="halauthorid">3187296-0</idno>
              <affiliation ref="#struct-467084"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Stefan</forename>
                <surname>Hoerer</surname>
              </persName>
              <idno type="halauthorid">3187297-0</idno>
              <affiliation ref="#struct-467084"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Oliver</forename>
                <surname>Hucke</surname>
              </persName>
              <idno type="idhal" notation="numeric">1397290</idno>
              <idno type="halauthorid" notation="string">3187298-1397290</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-1842-3426</idno>
              <affiliation ref="#struct-467084"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Christophe</forename>
                <surname>Joseph</surname>
              </persName>
              <idno type="halauthorid">3187299-0</idno>
              <affiliation ref="#struct-1776601"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Brigitte</forename>
                <surname>Kieffer</surname>
              </persName>
              <email type="md5">5fdc91e0594d47615ef1ddec2a55604e</email>
              <email type="domain">igbmc.u-strasbg.fr</email>
              <idno type="idhal" notation="numeric">844352</idno>
              <idno type="halauthorid" notation="string">620510-844352</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-8809-8334</idno>
              <idno type="IDREF">https://www.idref.fr/060613653</idno>
              <affiliation ref="#struct-134741"/>
              <affiliation ref="#struct-1772784"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Louison</forename>
                <surname>Lebrun</surname>
              </persName>
              <idno type="halauthorid">3187300-0</idno>
              <affiliation ref="#struct-1776601"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Noémie</forename>
                <surname>Lotz</surname>
              </persName>
              <idno type="halauthorid">3187301-0</idno>
              <affiliation ref="#struct-1776601"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Stanislas</forename>
                <surname>Mayer</surname>
              </persName>
              <idno type="halauthorid">2336595-0</idno>
              <affiliation ref="#struct-1776601"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Azar</forename>
                <surname>Omrani</surname>
              </persName>
              <idno type="halauthorid">3187302-0</idno>
              <affiliation ref="#struct-467084"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Mandy</forename>
                <surname>Recolet</surname>
              </persName>
              <idno type="halauthorid">3187303-0</idno>
              <affiliation ref="#struct-1776601"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Laurent</forename>
                <surname>Schaeffer</surname>
              </persName>
              <idno type="halauthorid">147043-0</idno>
              <affiliation ref="#struct-1776601"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Stephan</forename>
                <surname>Schann</surname>
              </persName>
              <idno type="halauthorid">350107-0</idno>
              <affiliation ref="#struct-1776601"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Annette</forename>
                <surname>Schlecker</surname>
              </persName>
              <idno type="halauthorid">3187304-0</idno>
              <affiliation ref="#struct-467084"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Edith</forename>
                <surname>Steinberg</surname>
              </persName>
              <idno type="halauthorid">3187305-0</idno>
              <affiliation ref="#struct-1776601"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Mélanie</forename>
                <surname>Viloria</surname>
              </persName>
              <idno type="halauthorid">3187306-0</idno>
              <affiliation ref="#struct-1776601"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Klaus</forename>
                <surname>Würstle</surname>
              </persName>
              <idno type="halauthorid">3187307-0</idno>
              <affiliation ref="#struct-467084"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Kyle</forename>
                <surname>Young</surname>
              </persName>
              <idno type="halauthorid">2486152-0</idno>
              <affiliation ref="#struct-467084"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Alexander</forename>
                <surname>Zinser</surname>
              </persName>
              <idno type="halauthorid">3187308-0</idno>
              <affiliation ref="#struct-467084"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Florian</forename>
                <surname>Montel</surname>
              </persName>
              <idno type="idhal" notation="numeric">1397291</idno>
              <idno type="halauthorid" notation="string">3187309-1397291</idno>
              <idno type="ORCID">https://orcid.org/0009-0002-7424-8976</idno>
              <affiliation ref="#struct-467084"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Julian</forename>
                <surname>Klepp</surname>
              </persName>
              <idno type="halauthorid">3187310-0</idno>
              <affiliation ref="#struct-467084"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Louise</forename>
                <surname>DESSAIVRE</surname>
              </persName>
              <email type="md5">685d55eef963fb90de2023edc9d11c27</email>
              <email type="domain">u-picardie.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2024-07-03 10:24:35</date>
              <date type="whenModified">2026-05-12 03:20:31</date>
              <date type="whenReleased">2024-07-03 10:24:35</date>
              <date type="whenProduced">2024-07-11</date>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="799781">
                <persName>
                  <forename>Louise</forename>
                  <surname>DESSAIVRE</surname>
                </persName>
                <email type="md5">685d55eef963fb90de2023edc9d11c27</email>
                <email type="domain">u-picardie.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-04633156</idno>
            <idno type="halUri">https://u-picardie.hal.science/hal-04633156</idno>
            <idno type="halBibtex">fer:hal-04633156</idno>
            <idno type="halRefHtml">&lt;i&gt;Journal of Medicinal Chemistry&lt;/i&gt;, 2024, 67 (13), pp.11296-11325. &lt;a target="_blank" href="https://dx.doi.org/10.1021/acs.jmedchem.4c00665"&gt;&amp;#x27E8;10.1021/acs.jmedchem.4c00665&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Journal of Medicinal Chemistry, 2024, 67 (13), pp.11296-11325. &amp;#x27E8;10.1021/acs.jmedchem.4c00665&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="UNIV-PICARDIE">Université de Picardie Jules Verne</idno>
            <idno type="stamp" n="UNIV-STRASBG">Université de Strasbourg</idno>
            <idno type="stamp" n="SITE-ALSACE">Archive ouverte du site Alsace</idno>
            <idno type="stamp" n="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="U-PICARDIE">Université de Picardie Jules Verne</idno>
            <idno type="stamp" n="GRAP" corresp="U-PICARDIE">Groupe de Recherche sur l'alcool et les pharmacodépendances - UMR INSERM_S 1247</idno>
            <idno type="stamp" n="ACADEMIE-SCIENCES">Académie des sciences</idno>
            <idno type="stamp" n="UNIVOAK">UNIVOAK</idno>
            <idno type="stamp" n="UMRS1329STEP">Neuroscience et Psychiatrie Translationnelle de Strasbourg </idno>
            <idno type="stamp" n="ACADEMIE-SCIENCES-PUBLICATIONS-MEMBRES" corresp="ACADEMIE-SCIENCES">Publications des membres, correspondants et associés étrangers de l'Académie des sciences</idno>
            <idno type="stamp" n="ACADEMIE-SCIENCES-PUBLICATIONS-MEMBRES-2" corresp="ACADEMIE-SCIENCES-PUBLICATIONS-MEMBRES">Publications des membres de l'Académie des sciences (lot 2)</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Discovery of BI-9508, a Brain-Penetrant GPR88-Receptor-Agonist Tool Compound for In Vivo Mouse Studies</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Mickael</forename>
                    <surname>Fer</surname>
                  </persName>
                  <idno type="halauthorid">3187288-0</idno>
                  <affiliation ref="#struct-1776601"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Camille</forename>
                    <surname>Amalric</surname>
                  </persName>
                  <idno type="halauthorid">250749-0</idno>
                  <affiliation ref="#struct-1776601"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Roberto</forename>
                    <surname>Arban</surname>
                  </persName>
                  <idno type="halauthorid">3187289-0</idno>
                  <affiliation ref="#struct-467084"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Luc</forename>
                    <surname>Baron</surname>
                  </persName>
                  <idno type="halauthorid">1168107-0</idno>
                  <affiliation ref="#struct-1776601"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sami</forename>
                    <surname>Ben Hamida</surname>
                  </persName>
                  <email type="md5">61b3ab409d17245f9bffae16a08947f5</email>
                  <email type="domain">u-picardie.fr</email>
                  <idno type="idhal" notation="string">sami-ben-hamida</idno>
                  <idno type="idhal" notation="numeric">1082082</idno>
                  <idno type="halauthorid" notation="string">697238-1082082</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-9636-9432</idno>
                  <idno type="IDREF">https://www.idref.fr/151197873</idno>
                  <affiliation ref="#struct-580112"/>
                  <affiliation ref="#struct-134741"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Petra</forename>
                    <surname>Breh-Schlanser</surname>
                  </persName>
                  <idno type="halauthorid">3187290-0</idno>
                  <affiliation ref="#struct-467084"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Yunhai</forename>
                    <surname>Cui</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1397289</idno>
                  <idno type="halauthorid" notation="string">3187291-1397289</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-4969-072X</idno>
                  <affiliation ref="#struct-467084"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Emmanuel</forename>
                    <surname>Darcq</surname>
                  </persName>
                  <email type="md5">c25420680a259ea445e261320d5d94e5</email>
                  <email type="domain">unistra.fr</email>
                  <idno type="idhal" notation="string">emmanuel-darcq</idno>
                  <idno type="idhal" notation="numeric">769181</idno>
                  <idno type="halauthorid" notation="string">731570-769181</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-8377-8015</idno>
                  <affiliation ref="#struct-508848"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Christian</forename>
                    <surname>Eickmeier</surname>
                  </persName>
                  <idno type="halauthorid">3187292-0</idno>
                  <affiliation ref="#struct-467084"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Vincent</forename>
                    <surname>Faye</surname>
                  </persName>
                  <idno type="halauthorid">3187293-0</idno>
                  <affiliation ref="#struct-1776601"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Christel</forename>
                    <surname>Franchet</surname>
                  </persName>
                  <idno type="halauthorid">345394-0</idno>
                  <affiliation ref="#struct-1776601"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Mélanie</forename>
                    <surname>Frauli</surname>
                  </persName>
                  <idno type="halauthorid">350105-0</idno>
                  <affiliation ref="#struct-1776601"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Célia</forename>
                    <surname>Halter</surname>
                  </persName>
                  <idno type="halauthorid">3187294-0</idno>
                  <affiliation ref="#struct-1776601"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marjorie</forename>
                    <surname>Heyer</surname>
                  </persName>
                  <idno type="halauthorid">3187295-0</idno>
                  <affiliation ref="#struct-1776601"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Christoph</forename>
                    <surname>Hoenke</surname>
                  </persName>
                  <idno type="halauthorid">3187296-0</idno>
                  <affiliation ref="#struct-467084"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Stefan</forename>
                    <surname>Hoerer</surname>
                  </persName>
                  <idno type="halauthorid">3187297-0</idno>
                  <affiliation ref="#struct-467084"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Oliver</forename>
                    <surname>Hucke</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1397290</idno>
                  <idno type="halauthorid" notation="string">3187298-1397290</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-1842-3426</idno>
                  <affiliation ref="#struct-467084"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Christophe</forename>
                    <surname>Joseph</surname>
                  </persName>
                  <idno type="halauthorid">3187299-0</idno>
                  <affiliation ref="#struct-1776601"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Brigitte</forename>
                    <surname>Kieffer</surname>
                  </persName>
                  <email type="md5">5fdc91e0594d47615ef1ddec2a55604e</email>
                  <email type="domain">igbmc.u-strasbg.fr</email>
                  <idno type="idhal" notation="numeric">844352</idno>
                  <idno type="halauthorid" notation="string">620510-844352</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-8809-8334</idno>
                  <idno type="IDREF">https://www.idref.fr/060613653</idno>
                  <affiliation ref="#struct-134741"/>
                  <affiliation ref="#struct-1772784"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Louison</forename>
                    <surname>Lebrun</surname>
                  </persName>
                  <idno type="halauthorid">3187300-0</idno>
                  <affiliation ref="#struct-1776601"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Noémie</forename>
                    <surname>Lotz</surname>
                  </persName>
                  <idno type="halauthorid">3187301-0</idno>
                  <affiliation ref="#struct-1776601"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Stanislas</forename>
                    <surname>Mayer</surname>
                  </persName>
                  <idno type="halauthorid">2336595-0</idno>
                  <affiliation ref="#struct-1776601"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Azar</forename>
                    <surname>Omrani</surname>
                  </persName>
                  <idno type="halauthorid">3187302-0</idno>
                  <affiliation ref="#struct-467084"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Mandy</forename>
                    <surname>Recolet</surname>
                  </persName>
                  <idno type="halauthorid">3187303-0</idno>
                  <affiliation ref="#struct-1776601"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Laurent</forename>
                    <surname>Schaeffer</surname>
                  </persName>
                  <idno type="halauthorid">147043-0</idno>
                  <affiliation ref="#struct-1776601"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Stephan</forename>
                    <surname>Schann</surname>
                  </persName>
                  <idno type="halauthorid">350107-0</idno>
                  <affiliation ref="#struct-1776601"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Annette</forename>
                    <surname>Schlecker</surname>
                  </persName>
                  <idno type="halauthorid">3187304-0</idno>
                  <affiliation ref="#struct-467084"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Edith</forename>
                    <surname>Steinberg</surname>
                  </persName>
                  <idno type="halauthorid">3187305-0</idno>
                  <affiliation ref="#struct-1776601"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Mélanie</forename>
                    <surname>Viloria</surname>
                  </persName>
                  <idno type="halauthorid">3187306-0</idno>
                  <affiliation ref="#struct-1776601"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Klaus</forename>
                    <surname>Würstle</surname>
                  </persName>
                  <idno type="halauthorid">3187307-0</idno>
                  <affiliation ref="#struct-467084"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Kyle</forename>
                    <surname>Young</surname>
                  </persName>
                  <idno type="halauthorid">2486152-0</idno>
                  <affiliation ref="#struct-467084"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Alexander</forename>
                    <surname>Zinser</surname>
                  </persName>
                  <idno type="halauthorid">3187308-0</idno>
                  <affiliation ref="#struct-467084"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Florian</forename>
                    <surname>Montel</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1397291</idno>
                  <idno type="halauthorid" notation="string">3187309-1397291</idno>
                  <idno type="ORCID">https://orcid.org/0009-0002-7424-8976</idno>
                  <affiliation ref="#struct-467084"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Julian</forename>
                    <surname>Klepp</surname>
                  </persName>
                  <idno type="halauthorid">3187310-0</idno>
                  <affiliation ref="#struct-467084"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">15785</idno>
                <idno type="issn">0022-2623</idno>
                <idno type="eissn">1520-4804</idno>
                <title level="j">Journal of Medicinal Chemistry</title>
                <imprint>
                  <publisher>American Chemical Society</publisher>
                  <biblScope unit="volume">67</biblScope>
                  <biblScope unit="issue">13</biblScope>
                  <biblScope unit="pp">11296-11325</biblScope>
                  <date type="datePub">2024-07-11</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1021/acs.jmedchem.4c00665</idno>
              <idno type="pubmed">38949964</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="scco.neur">Cognitive science/Neuroscience</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Decreased activity and expression of the G-protein coupled receptor GPR88 is linked to many behavior-linked neurological disorders. Published preclinical GPR88 allosteric agonists all have in vivo pharmacokinetic properties that preclude their progression to the clinic, including high lipophilicity and poor brain penetration. Here, we describe our attempts to improve GPR88 agonists' drug-like properties and our analysis of the trade-offs required to successfully target GPR88's allosteric pocket. We discovered two new GPR88 agonists: One that reduced morphine-induced locomotor activity in a murine proof-of-concept study, and the atropoisomeric BI-9508, which is a brain penetrant and has improved pharmacokinetic properties and dosing that recommend it for future in vivo studies in rodents. BI-9508 still suffers from high lipophilicity, and research on this series was halted. Because of its utility as a tool compound, we now offer researchers access to BI-9508 and a negative control free of charge via Boehringer Ingelheim's open innovation portal opnMe.com.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="institution" xml:id="struct-1776601" status="VALID">
          <orgName>Domain Therapeutics [Illkirch]</orgName>
          <orgName type="acronym">DT</orgName>
          <desc>
            <address>
              <addrLine>220 Bd Gonthier d'Andernach, 67400 Illkirch-Graffenstaden</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.domaintherapeutics.com/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-467084" status="VALID">
          <orgName>Boehringer Ingelheim Pharma GmbH &amp; Co. KG</orgName>
          <desc>
            <address>
              <addrLine>Birkendorfer Strasse 65, 88397 Biberach an der Riss, Germany.</addrLine>
              <country key="DE"/>
            </address>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-580112" status="VALID">
          <idno type="IdRef">195706684</idno>
          <idno type="RNSR">200720140R</idno>
          <idno type="ROR">https://ror.org/01c62av11</idno>
          <orgName>Groupe de Recherche sur l'alcool et les pharmacodépendances - UMR INSERM_S 1247 UPJV</orgName>
          <orgName type="acronym">GRAP</orgName>
          <date type="start">2007-01-01</date>
          <desc>
            <address>
              <addrLine>Université de Picardie Jules Verne - CURS - CHU Sud - avenue Laënnec - 80054 AMIENS CEDEX 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://grap.u-picardie.fr</ref>
          </desc>
          <listRelation>
            <relation name="ERI24" active="#struct-300258" type="direct"/>
            <relation name="U1247" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-134741" status="VALID">
          <idno type="ROR">https://ror.org/01pxwe438</idno>
          <orgName>McGill University = Université McGill [Montréal, Canada]</orgName>
          <desc>
            <address>
              <addrLine>845, rue Sherbrooke O. Montréal (Québec) Canada H3A 0G4</addrLine>
              <country key="CA"/>
            </address>
            <ref type="url">http://www.mcgill.ca/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-508848" status="INCOMING">
          <orgName>Douglas Hospital Research Center, Department of Psychiatry, Faculty of Medicine</orgName>
          <desc>
            <address>
              <country key="CA"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-134741" type="direct"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-1772784" status="VALID">
          <orgName>Equipe "Addiction" de l'U1329</orgName>
          <date type="start">2024-01-01</date>
          <desc>
            <address>
              <addrLine>CRBS - 1 rue Eugène Boeckel - CS 60026 - 67084 Strasbourg Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://step.unistra.fr/addictions/presentation-team-addictions/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1188214" type="direct"/>
            <relation name="UMRS1329" active="#struct-199013" type="indirect"/>
            <relation name="U1329" active="#struct-303623" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300258" status="VALID">
          <idno type="IdRef">026403714</idno>
          <idno type="ISNI">0000 0001 0789 1385</idno>
          <idno type="ROR">https://ror.org/01gyxrk03</idno>
          <orgName>Université de Picardie Jules Verne</orgName>
          <orgName type="acronym">UPJV</orgName>
          <desc>
            <address>
              <addrLine>Chemin du Thil - 80000 Amiens</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.u-picardie.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-1188214" status="VALID">
          <idno type="IdRef">275313247</idno>
          <idno type="RNSR">202424457J</idno>
          <idno type="ROR">https://ror.org/05dd6kb95</idno>
          <orgName>Neuroscience et Psychiatrie Translationnelle de Strasbourg</orgName>
          <orgName type="acronym">STEP</orgName>
          <date type="start">2024-01-01</date>
          <desc>
            <address>
              <addrLine>CRBS 1 rue Eugène Boeckel67000 Strasbourg</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://step.unistra.fr/</ref>
          </desc>
          <listRelation>
            <relation name="UMRS1329" active="#struct-199013" type="direct"/>
            <relation name="U1329" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-199013" status="VALID">
          <idno type="IdRef">131056549</idno>
          <idno type="ROR">https://ror.org/00pg6eq24</idno>
          <orgName>Université de Strasbourg</orgName>
          <orgName type="acronym">UNISTRA</orgName>
          <desc>
            <address>
              <addrLine>4 rue Blaise Pascal - CS 90032 - 67081 Strasbourg cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.unistra.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>