Seroepidemiology of the Seasonal Human Coronaviruses NL63, 229E, OC43 and HKU1 in France - Agents infectieux, résistance et chimiothérapie - UR UPJV 4294 Accéder directement au contenu
Article Dans Une Revue Open Forum Infectious Diseases Année : 2023

Seroepidemiology of the Seasonal Human Coronaviruses NL63, 229E, OC43 and HKU1 in France

Résumé

Background. The seasonal human coronaviruses (HCoV) NL63, 229E, OC43, and HKU1 are globally endemic, yet the majority of HCoV infections remain undiagnosed. Methods. In a cross-sectional study, 2389 serum samples were collected from children and adults in France in 2020. In a longitudinal cohort study, 2520 samples were collected from 898 French individuals followed up between 2020 and 2021. Antibodies to HCoVs were measured using a bead-based multiplex assay. Results. The rate of waning of anti-HCoV spike immunoglobulin G antibodies was estimated as 0.22-0.47 year −1 for children, and 0.13-0.27 year −1 for adults. Seroreversion was estimated as 0.31-1.37 year −1 in children and 0.19-0.72 year −1 in adults. The estimated seroconversion rate in children was consistent with 20%-39% of children being infected every year with each HCoV. Conclusions. The high force of infection in children indicates that HCoVs may be responsible for a substantial proportion of fever episodes experienced by children.
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hal-04187240 , version 1 (24-08-2023)

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Alix de Thoisy, Tom Woudenberg, Stéphane Pelleau, Françoise Donnadieu, Laura Garcia, et al.. Seroepidemiology of the Seasonal Human Coronaviruses NL63, 229E, OC43 and HKU1 in France. Open Forum Infectious Diseases, 2023, 10 (7), pp.1-9. ⟨10.1093/ofid/ofad340⟩. ⟨hal-04187240⟩
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