Prevalence and determinants of fatigue in patients with IBD: a cross-sectional survey from the GETAID. - Périnatalité et Risques Toxiques - UMR INERIS_I 1 Accéder directement au contenu
Article Dans Une Revue Journal of Crohn's and Colitis Année : 2023

Prevalence and determinants of fatigue in patients with IBD: a cross-sectional survey from the GETAID.

1 AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre)
2 CESP - Centre de recherche en épidémiologie et santé des populations
3 Hôpital Henri Mondor
4 Hôpital Beaujon [AP-HP]
5 Hôpital Nord [CHU - APHM]
6 Immunité muqueuse et vaccination
7 Service de Gastro-entérologie et Hépatologie [CHU Saint-Etienne]
8 CRSA - Centre de Recherche Saint-Antoine
9 NuMeCan - Nutrition, Métabolismes et Cancer
10 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou]
11 CIC - Centre d'Investigation Clinique [Rennes]
12 ULB - Hôpital Erasme [Bruxelles]
13 ADEN - Nutrition, Inflammation et axe Microbiote-Intestin-Cerveau
14 IRIB - Institute for Research and Innovation in Biomedicine
15 UNIROUEN UFR Santé - UNIROUEN - UFR Santé
16 Service d'Hépato-Gastroentérologie [CHU Rouen]
17 CHU Clermont-Ferrand
18 M2iSH - Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte
19 CHU-Liège - Centre Hospitalier Universitaire de Liège
20 HCL - Hospices Civils de Lyon
21 Service de Gastro-entérologie [CHU Cochin]
22 Voies de Signalisation du Développement et du Stress Cellulaire dans les Cancers Digestifs et Urologiques
23 KU Leuven - Catholic University of Leuven = Katholieke Universiteit Leuven
24 Service de Gastro-Entérologie [CHRU Besançon]
25 CHUGA - Centre Hospitalier Universitaire [CHU Grenoble]
26 NGERE - Nutrition-Génétique et Exposition aux Risques Environnementaux
27 Service d'Hépato-gastro-entérologie [CHRU Nancy]
28 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
29 AP-HP - Hopital Saint-Louis [AP-HP]
30 CHU Caen
31 Institut des Maladies de l'Appareil Digestif
32 CIC Nantes - Centre d’Investigation Clinique de Nantes
33 CHU Angers - Centre Hospitalier Universitaire d'Angers
34 CHU Montpellier
35 CHU Amiens-Picardie
36 PERITOX - Périnatalité et Risques Toxiques - UMR INERIS_I 1
37 CHU Nîmes - Centre Hospitalier Universitaire de Nîmes
38 CHU Bordeaux
39 INFINITE (Ex-Liric) - Institute for Translational Research in Inflammation - U 1286
Stephanie Viennot
  • Fonction : Auteur
Hedia Brixi
  • Fonction : Auteur
Claire Painchart
  • Fonction : Auteur
Laurianne Plastaras
  • Fonction : Auteur
Romain Altwegg
  • Fonction : Auteur
David Laharie
  • Fonction : Auteur

Résumé

Background: Fatigue is commonly reported by patients with inflammatory bowel disease (IBD), but the determinants of IBD-related fatigue have yet to be determined.Aims: To identify the factors associated with fatigue in a large population of patients with IBD.Patients and methods: Fatigue and nine other IBD-related disability dimensions were assessed in a cohort of 1704 consecutive patients with IBD using the IBD-disk questionnaire in a cross-sectional survey of 42 French and Belgian centers. Fatigue and severe fatigue were defined as energy subscores >5 and >7, respectively. Determinants of fatigue were assessed using univariate and multivariate analyses (odds ratios (ORs) are provided with 95% confidence intervals).Results: The prevalence rates of fatigue and severe fatigue were 54.1% and 37.1%, respectively. Both fatigue and severe fatigue were significantly higher in patients with active disease than in patients with inactive disease (64.9% vs. 44.7% and 47.4% vs. 28.6%, respectively; p<0.001 for both comparisons). In the multivariate analysis stratified by age, sex, type of IBD and IBD activity, fatigue was associated with age >40 years (OR=0.71 [0.54-0.93]), female sex (OR=1.48 [1.13-1.93]), IBD-related sick leave (OR=1.61 (1.19-2.16]), and joint pain (OR=1.60 [1.17-2.18]), abdominal pain (OR=1.78 [1.29-2.45]), regulating defecation (OR=1.67 [1.20-2.32]), education and work (OR=1.96 [1.40-2.75]), body image (OR=1.38 [1.02-1.86]), sleep (OR=3.60 [2.66-4.88]) and emotions (OR=3.60 [2.66-4.88]) subscores > 5.Conclusion: Determinants of fatigue are not restricted to IBD-related factors but also include social factors, sleep, and emotional disturbances, thus supporting a holistic approach to IBD patient care.
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hal-04052487 , version 1 (16-05-2023)

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Paternité - Pas d'utilisation commerciale

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Citer

Aurelien Amiot, Sayma Chaibi, Yoram Bouhnik, Melanie Serrero, Jerome Filippi, et al.. Prevalence and determinants of fatigue in patients with IBD: a cross-sectional survey from the GETAID.. Journal of Crohn's and Colitis, 2023, 17 (9), pp.1418-1425. ⟨10.1093/ecco-jcc/jjad060⟩. ⟨hal-04052487⟩
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