Does prenatal exposure to multiple airborne and tap-water pollutants increase neonatal thyroid-stimulating hormone concentrations? Data from the Picardy region, France - Périnatalité et Risques Toxiques - UMR INERIS_I 1 Accéder directement au contenu
Article Dans Une Revue Science of the Total Environment Année : 2023

Does prenatal exposure to multiple airborne and tap-water pollutants increase neonatal thyroid-stimulating hormone concentrations? Data from the Picardy region, France

Karine Braun
  • Fonction : Auteur

Résumé

Systematic screening for congenital hypothyroidism by heel-stick sampling has revealed unexpected heterogeneity in the geographic distribution of newborn thyroid-stimulating hormone concentrations in Picardy, France. We explored a possible relationship with environmental pollutants. Methods: Zip code geolocation data from mothers of newborns without congenital hypothyroidism born in were linked to ecological data for a set of airborne (particulate matter with a diameter of 2.5 μm or less [PM 2.5 ] or 10 μm or less [PM 10 ]) and tap-water (nitrate and perchlorate ions and atrazine) pollutants. Statistical associations between mean exposure levels during the third trimester of pregnancy and Thyroid-stimulating hormone (TSH) concentrations in 6249 newborns (51 % male) were investigated using linear regression models. Results: Median neonatal TSH concentration (interquartile range, IQR) was 1.7 (1-2.8) mIU/L. An increase of one IQR in prenatal exposure to perchlorate ions (3.6 μg/L), nitrate ions (19.2 mg/L), PM 2.5 (3.7 μg/m 3) and PM (3.4 μg/m 3), were associated with increases in TSH concentrations of 2.30 % (95 % CI: 0.95-3.66), 5.84 % (95 % CI: 2.81-8.87), 13.44 % (95 % CI: 9.65-17.28) and 6.26 % (95 % CI: 3.01-9.56), respectively. Conclusions: Prenatal exposure to perchlorate and nitrate ions in tap water and to airborne PM over the third trimester of pregnancy was significantly associated with increased neonatal TSH concentrations.
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Origine : Publication financée par une institution
licence : CC BY NC ND - Paternité - Pas d'utilisation commerciale - Pas de modification

Dates et versions

hal-04213094 , version 1 (26-09-2023)

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Paternité - Pas d'utilisation commerciale - Pas de modification

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Sylvain Chamot, Abdallah Al-Salameh, Pascal Petit, Vincent Bonneterre, Christophe Cancé, et al.. Does prenatal exposure to multiple airborne and tap-water pollutants increase neonatal thyroid-stimulating hormone concentrations? Data from the Picardy region, France. Science of the Total Environment, 2023, 905, pp.167089. ⟨10.1016/j.scitotenv.2023.167089⟩. ⟨hal-04213094⟩
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