Article Dans Une Revue Journal of Gastroenterology and Hepatology Année : 2019

Disease course of inflammatory bowel disease unclassified in a European population-based inception cohort: An Epi-IBD study

1 UCPH - Københavns Universitet = University of Copenhagen = Université de Copenhague
2 Mater Dei Hospital [Malta]
3 University of Moldova
4 ISCARE
5 UK - Univerzita Karlova [Praha, Česká republika] = Charles University [Prague, Czech Republic] = Université Charles [Prague, Republique tchèque]
6 Viborg Hospital
7 Regional Hospital West Jutland [Denmark]
8 SDU - University of Southern Denmark = Syddansk Universitet
9 CHU Amiens-Picardie
10 Registre EPIMAD
11 Service d'Epidémiologie et de Santé Publique [Lille]
12 INFINITE - Institute for Translational Research in Inflammation - U 1286
13 Unipd - Università degli Studi di Padova = University of Padua
14 G.B. Morgagni-Pierantoni Hospital [Forlì, Italy]
15 UMFT - Victor Babeş University of Medicine and Pharmacy
16 University Hospital Centre Zagreb
17 Tampere University Hospital
18 University of Tampere [Finland]
19 Hospital de São João [Porto]
20 Universidade do Porto = University of Porto
21 Imperial College London
22 Örebro University
23 Herning Hospital
24 OUH - Odense University Hospital
25 Hull and East Yorkshire Eye Hospital
26 University Hospital of Ioannina
27 National Hospital of the Faroe Islands [Tórshavn, Faroe Islands]
28 LSMU - Lithuanian University of health Sciences
29 MONICA - Moscow Regional Research Clinical Institute
30 BGU - Ben-Gurion University of the Negev
31 Tartu University Hospital
32 Instituto de Investigación Sanitaria Galicia Sur [Vigo, Spain]
33 Semmelweis University [Budapest]
34 MUHC - McGill University Health Center [Montreal]
Pierre Ellul
Dana Duricova
  • Fonction : Auteur
  • PersonId : 1450238
Ioannis P. Kaimakliotis
  • Fonction : Auteur
Mathurin Fumery
Natalia Pedersen
  • Fonction : Auteur
Amalia Carmona
  • Fonction : Auteur

Résumé

Background and Aim A definitive diagnosis of Crohn's disease (CD) or ulcerative colitis (UC) is not always possible, and a proportion of patients will be diagnosed as inflammatory bowel disease unclassified (IBDU). The aim of the study was to investigate the prognosis of patients initially diagnosed with IBDU and the disease course during the following 5 years. Methods The Epi-IBD study is a prospective population-based cohort of 1289 IBD patients diagnosed in centers across Europe. Clinical data were captured prospectively throughout the follow-up period. Results Overall, 476 (37%) patients were initially diagnosed with CD, 701 (54%) with UC, and 112 (9%) with IBDU. During follow-up, 28 (25%) IBDU patients were changed diagnoses to either UC (n = 20, 71%) or CD (n = 8, 29%) after a median of 6 months (interquartile range: 4-12), while 84 (7% of the total cohort) remained IBDU. A total of 17 (15%) IBDU patients were hospitalized for their IBD during follow-up, while 8 (7%) patients underwent surgery. Most surgeries (n = 6, 75%) were performed on patients whose diagnosis was later changed to UC; three of these colectomies led to a definitive diagnosis of UC. Most patients (n = 107, 96%) received 5-aminosalicylic acid, while 11 (10%) patients received biologicals, of whom five remained classified as IBDU. Conclusions In a population-based inception cohort, 7% of IBD patients were not given a definitive diagnosis of IBD after 5 years of follow-up. One in four patients with IBDU eventually was classified as CD or UC. Overall, the disease course and medication burden in IBDU patients were mild.

Dates et versions

hal-03552292 , version 1 (02-02-2022)

Identifiants

Citer

Johan Burisch, Stefania Chetcuti Zammit, Pierre Ellul, Svetlana Turcan, Dana Duricova, et al.. Disease course of inflammatory bowel disease unclassified in a European population-based inception cohort: An Epi-IBD study. Journal of Gastroenterology and Hepatology, 2019, 34 (6), pp.996-1003. ⟨10.1111/jgh.14563⟩. ⟨hal-03552292⟩
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