OP35 Natural history of anal ulcerations in pediatric-onset Crohn’s Disease: A population-based study - Université de Picardie Jules Verne Accéder directement au contenu
Article Dans Une Revue Journal of Crohn's and Colitis Année : 2022

OP35 Natural history of anal ulcerations in pediatric-onset Crohn’s Disease: A population-based study

Résumé

Background Anal ulcerations are frequently observed in Crohn’s disease (CD). Their natural history remains poorly known, especially in pediatric-onset CD. The aims of this study were: to determine in a population-based study the risk of anal ulcerations in pediatric onset CD; to identify risk factors for anal ulcerations; to evaluate the risk of progression towards suppurative lesions; to evaluate the risk factors of progression towards suppurative lesions. Methods All patients with a diagnosis of CD before the age of 17 years between 1988 and 2011 within the population-based registry EPIMAD were followed retrospectively until 2013. A specific collection of additional data was performed in patients with anal ulcerations at diagnosis or during follow-up. The variables collected included: proctological examination, diagnostic management (perineal MRI, endoscopic ultrasound, examination under general anaesthesia) and treatment (medical or surgical). Multivariate Cox models were used to identify factors associated with anal ulcerations and factors of progression towards suppurative lesions. An adjusted time-dependent Cox model was used to evaluate the risk of progression of anal ulcerations towards suppurative lesions. Results 1005 patients were included (females, 450 (44.8%); median age at diagnosis 14.4 years (IQR, 12.0–16.1)). 257 (25.6%) had anal ulceration at diagnosis. Cumulative incidence of anal ulceration at 5 and 10 years from diagnosis was 38.4% (CI95%, 35.2–41.4) and 44.0% (CI95%, 40.5–47.2).

Dates et versions

hal-03665874 , version 1 (12-05-2022)

Licence

Identifiants

Citer

Perrine Mortreux, A. Leroyer, C. Dupont, D. Ley, V. Bertrand, et al.. OP35 Natural history of anal ulcerations in pediatric-onset Crohn’s Disease: A population-based study. Journal of Crohn's and Colitis, 2022, 16 (1), pp.i041-i042. ⟨10.1093/ecco-jcc/jjab232.034⟩. ⟨hal-03665874⟩
45 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More