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Article Dans Une Revue Antibiotics Année : 2024

One Hundred Explicit Definitions of Potentially Inappropriate Prescriptions of Antibiotics in Hospitalized Older Patients: The Results of an Expert Consensus Study

1 METRICS - Evaluation des technologies de santé et des pratiques médicales - ULR 2694
2 Groupement Hospitalier de l'Institut Catholique de Lille
3 Centre Hospitalier Métropole Savoie [Chambéry]
4 UNIMIB - Università degli Studi di Milano-Bicocca = University of Milano-Bicocca
5 CHU Bordeaux
6 Centre Hospitalier de Roubaix
7 Centre Hospitalier Gustave Dron [Tourcoing]
8 Service de médecine interne, immunologie clinique [Béclère]
9 CESP - Centre de recherche en épidémiologie et santé des populations
10 CHU ST-E - Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne]
11 GIMAP - Groupe Immunité des Muqueuses et Agents Pathogènes
12 CIC-EC 1408 - Centre d'Investigation Clinique - Epidémiologie Clinique [CHU Saint-Etienne]
13 Service des Maladies Infectieuses et Tropicales [CHRU Nancy]
14 Service de maladies infectieuses [CH Melun]
15 CHAC - Centre Hospitalier Alès-Cévennes
16 CHU - BREST - Rhumato - CHRU Brest - Service de Rhumatologie
17 VIEFRA - EA 3797 - Vieillissement, Fragilité
18 Service de Médecine interne, Maladies Infectieuses et Immunologie Clinique [Reims]
19 Maladies infectieuses et tropicales [CHU Amiens]
20 AGIR - Agents infectieux, résistance et chimiothérapie - UR UPJV 4294
21 CHU de Poitiers [La Milétrie] - Centre hospitalier universitaire de Poitiers = Poitiers University Hospital
22 Service de médecine gériatrique (CHU de Dijon - Centre gériatrique de Champmaillot - EHPAD)
23 CHU Strasbourg - Centre Hospitalier Universitaire [Strasbourg]
24 CRIOAC-Lille-Tourcoing - Centre de Référence des Infections Ostéo-Articulaires Complexes Nord-Ouest
Claire Roubaud-Baudron
Vincent Hiernard
  • Fonction : Auteur
Serge Alfandari
Pauline Caraux-Paz
Thibaut Fraisse
Pierre Gazeau
Yvon Ruch

Résumé

Background: In geriatrics, explicit criteria for potentially inappropriate prescriptions (PIPs) are useful for optimizing drug use. Objective: To produce an expert consensus on explicit definitions of antibiotic-PIPs for hospitalized older patients. Methods: We conducted a Delphi survey involving French experts on antibiotic stewardship in hospital settings. During the survey’s rounds, the experts gave their opinion on each explicit definition, and could suggest new definitions. Definitions with a 1-to-9 Likert score of between 7 and 9 from at least 75% of the participants were adopted. The results were discussed during consensus meetings after each round. Results: Of the 155 invited experts, 128 (82.6%) participated in the whole survey: 59 (46%) infectious diseases specialists, 45 (35%) geriatricians, and 24 (19%) other specialists. In Round 1, 65 explicit definitions were adopted and 21 new definitions were suggested. In Round 2, 35 other explicit definitions were adopted. The results were validated during consensus meetings (with 44 participants after Round 1, and 54 after Round 2). Conclusions: The present study is the first to have provided a list of explicit definitions of potentially inappropriate antibiotic prescriptions for hospitalized older patients. It might help to disseminate key messages to prescribers and reduce inappropriate prescriptions of antibiotics.

Dates et versions

hal-04516422 , version 1 (22-03-2024)

Identifiants

Citer

Nicolas Baclet, Emmanuel Forestier, Gaëtan Gavazzi, Claire Roubaud-Baudron, Vincent Hiernard, et al.. One Hundred Explicit Definitions of Potentially Inappropriate Prescriptions of Antibiotics in Hospitalized Older Patients: The Results of an Expert Consensus Study. Antibiotics, 2024, 13 (3), pp.283. ⟨10.3390/antibiotics13030283⟩. ⟨hal-04516422⟩
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