Chapitre D'ouvrage Année : 2023

The Dualistic Role of Macrophages in Aortic Valve Calcification

Résumé

Calcific aortic valve stenosis (CAS) is the most common valvular heart disease worldwide, associated with cardiovascular morbidity and mortality. This pathology results from fibro- calcific degeneration of the aortic valve leaflets, causing major cardiovascular complications. To date, drug therapies have been ineffective in preventing the progression of CAS and aortic valve replacement remains the mainstay of management for patients with symptomatic CAS. Unfortunately, not all patients are eligible for this procedure, which is associated with a greater risk of mortality for subjects presenting comorbidities. A better understanding of the mechanisms responsible for CAS pathogenesis is therefore of crucial importance to develop new therapeutic strategies. Inflammation is a key driver of aortic valve fibrosis and calcification. Macrophages, which play critical roles in the induction and resolution of sterile inflammation, may therefore represent interesting therapeutic targets. Once infiltrated within the aortic leaflet, these dynamic cells can adopt a pro-inflammatory M1 phenotype or switch toward an alternatively activated M2 phenotype, resulting in wound healing and anti-inflammatory activities. This plasticity complicates the efforts to understand their role in the initiation and progression of CAS. This book chapter aims to summarize our current knowledge regarding the role played by macrophage subsets on aortic valve remodelling.
Fichier principal
Vignette du fichier
The-Dualistic-Role-of-Macrophages-in-Aortic-Valve-Calcification.pdf (291.37 Ko) Télécharger le fichier
Origine Publication financée par une institution

Dates et versions

hal-04652978 , version 1 (18-07-2024)

Identifiants

  • HAL Id : hal-04652978 , version 1

Citer

Nervana Issa, Alexandre Candellier, Cédric Boudot, Saïd Kamel, Lucie Hénaut. The Dualistic Role of Macrophages in Aortic Valve Calcification. Hussein Fayyad Kazan (dir.). Immunology and Cancer Biology, Vide Leaf, 2023, 978-81-953047-2-1. ⟨hal-04652978⟩

Collections

U-PICARDIE MP3CV
12 Consultations
9 Téléchargements

Partager

More