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Article Dans Une Revue Pediatric Pulmonology Année : 2018

The hypoxic test in preterm neonates reinvestigated

Christelle Kouakam
Andre Leke
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Guy Kongolo


AimWe currently lack a suitable gold-standard method for implementation on modern equipment to assess peripheral chemoreceptor sensitivity. The aim of the present study was to develop an accurate and reproducible method for assessing peripheral chemoreceptors sensitivity in sleeping preterm neonates. MethodsA poikilocapnic hypoxic test was performed twice during rapid eye movement sleep (REM sleep) and non-rapid eye movement sleep (nonREM sleep). The infant breathed hypoxic gas (15% O-2) for 60s. The ventilatory response to hypoxia was assessed by comparing minute ventilation during the control period (21% O-2) with successive 4-cycles sequences during hypoxia. We detected the first statistically significant increase in minute ventilation and recorded the corresponding response time. ResultsDuring normoxia, minute ventilation was higher during REM sleep than in nonREM sleep (428.1mLmin(-1)kg(-1) [307.7-633.6]; 388.8mLmin(-1)kg(-1) [264.7-608.0], respectively; P=0.001). After hypoxia, minute ventilation increased in both REM and nonREM sleep. The response was significantly higher in REM than in nonREM (25.3% [10.8-80.0] and 16.8% [7.5-33.2], respectively; P=0.005). The intraclass correlation coefficients for all respiratory parameters were above 0.90. ConclusionWe have developed a highly reliable method for assessing peripheral chemoreceptors sensitivity at the response time to hypoxia. In the future, researchers could use this method to assess the involvement of peripheral chemoreceptors in infants who experience chronic hypoxia (e.g. in bronchopulmonary dysplasia and recurrent apnea).
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Dates et versions

hal-03549891 , version 1 (31-01-2022)



Christelle Kouakam, Erwan Stephan, Andre Leke, Guy Kongolo, Elodie Haraux, et al.. The hypoxic test in preterm neonates reinvestigated. Pediatric Pulmonology, 2018, 53 (4), pp.483-491. ⟨10.1002/ppul.23907⟩. ⟨hal-03549891⟩


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