Non-Coding RNAs in Kidney Diseases: The Long and Short of Them - Université de Picardie Jules Verne Accéder directement au contenu
Article Dans Une Revue International Journal of Molecular Sciences Année : 2021

Non-Coding RNAs in Kidney Diseases: The Long and Short of Them

Résumé

Recent progress in genomic research has highlighted the genome to be much more transcribed than expected. The formerly so-called junk DNA encodes a miscellaneous group of largely unknown RNA transcripts, which contain the long non-coding RNAs (lncRNAs) family. lncRNAs are instrumental in gene regulation. Moreover, understanding their biological roles in the physiopathology of many diseases, including renal, is a new challenge. lncRNAs regulate the effects of microRNAs (miRNA) on mRNA expression. Understanding the complex crosstalk between lncRNA-miRNA-mRNA is one of the main challenges of modern molecular biology. This review aims to summarize the role of lncRNA on kidney diseases, the molecular mechanisms involved, and their function as emerging prognostic biomarkers for both acute and chronic kidney diseases. Finally, we will also outline new therapeutic opportunities to diminish renal injury by targeting lncRNA with antisense oligonucleotides.
Fichier principal
Vignette du fichier
Moreno et al IJMS 2021.pdf (725.11 Ko) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte
Licence

Dates et versions

hal-03584404 , version 1 (20-04-2023)

Licence

Identifiants

Citer

Juan Antonio Moreno, Eya Hamza, Melania Guerrero-Hue, Sandra Rayego-Mateos, Cristina Garcia-Caballero, et al.. Non-Coding RNAs in Kidney Diseases: The Long and Short of Them. International Journal of Molecular Sciences, 2021, 22 (11), pp.6077. ⟨10.3390/ijms22116077⟩. ⟨hal-03584404⟩
31 Consultations
22 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More