EHealth appears to be both an economic solution and a way to overcome the increase in health needs due to the ageing of the population and the increase of diseases. The presented project is aimed at developing individualized monitoring of patients who have undergone surgery and have been supported by a medical information system and connected devices. These connected systems have many benefits for healthcare system, but they also have disadvantages, relating to the complexity of their use. Their evaluation must be done in real work situations with health professionals and patients with different profiles (age, needs, skills, literacy, pathology, and expert/novice in technologies.). The aim of this work is to propose an integrative theoretical and methodological framework for a standardized evaluation of usability (including efficiency, effectiveness, satisfaction and understanding) in e-health in a user-centered design context. To do this, below is presented a state-of-the-art on usability evaluation. Finally, this work presents insights on how ergonomics and cognitive psychology approaches can contribute to greater understanding and the use of these devices in healthcare (patients, caregivers, family careers).