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Article Dans Une Revue Current Organic Chemistry Année : 2016

Glycochemical Applications of Diels-Alder Reaction


Carbohydrates and their analogs are key molecules with a wide range of biological activities. These bioactive compounds are usually synthesized through derivatization of naturally occurring carbohydrates. Nevertheless, this strategy suffers from a limited range of naturally available monosaccharide building blocks and the necessity of laborious steps of protection and deprotection. Consequently new methods began to emerge and Diels-Alder reaction appeared to be a method of choice for their de novo production. The synthesis of carbohydrates and their analogs by means of cycloaddition reactions will be reviewed here. Moreover the potentiality of the use of monosaccharides to induce chirality in Diels-Alder reaction will be presented. Efficient methods for the synthesis of di- and trisaccharides using the developments shown previously will be also introduced.


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Dates et versions

hal-03613826 , version 1 (18-03-2022)



Sylvain Laclef, Sylvestre Toumieux, Jose Kovensky. Glycochemical Applications of Diels-Alder Reaction. Current Organic Chemistry, 2016, 20 (22), pp.2379-2392. ⟨10.2174/1385272820666160502163125⟩. ⟨hal-03613826⟩
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