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Article Dans Une Revue International Journal of Molecular Sciences Année : 2022

Crosstalk between Ca(2+) Signaling and Cancer Stemness: The Link to Cisplatin Resistance.

Sana Kouba
Frédéric Hague
Ahmed Ahidouch
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In the fight against cancer, therapeutic strategies using cisplatin are severely limited by the appearance of a resistant phenotype. While cisplatin is usually efficient at the beginning of the treatment, several patients endure resistance to this agent and face relapse. One of the reasons for this resistant phenotype is the emergence of a cell subpopulation known as cancer stem cells (CSCs). Due to their quiescent phenotype and self-renewal abilities, these cells have recently been recognized as a crucial field of investigation in cancer and treatment resistance. Changes in intracellular calcium (Ca(2+)) through Ca(2+) channel activity are essential for many cellular processes such as proliferation, migration, differentiation, and survival in various cell types. It is now proved that altered Ca(2+) signaling is a hallmark of cancer, and several Ca(2+) channels have been linked to CSC functions and therapy resistance. Moreover, cisplatin was shown to interfere with Ca(2+) homeostasis; thus, it is considered likely that cisplatin-induced aberrant Ca(2+) signaling is linked to CSCs biology and, therefore, therapy failure. The molecular signature defining the resistant phenotype varies between tumors, and the number of resistance mechanisms activated in response to a range of pressures dictates the global degree of cisplatin resistance. However, if we can understand the molecular mechanisms linking Ca(2+) to cisplatin-induced resistance and CSC behaviors, alternative and novel therapeutic strategies could be considered. In this review, we examine how cisplatin interferes with Ca(2+) homeostasis in tumor cells. We also summarize how cisplatin induces CSC markers in cancer. Finally, we highlight the role of Ca(2+) in cancer stemness and focus on how they are involved in cisplatin-induced resistance through the increase of cancer stem cell populations and via specific pathways.

Dates et versions

hal-03792024 , version 1 (29-09-2022)



Sana Kouba, Frédéric Hague, Ahmed Ahidouch, Halima Ouadid-Ahidouch. Crosstalk between Ca(2+) Signaling and Cancer Stemness: The Link to Cisplatin Resistance.. International Journal of Molecular Sciences, 2022, 23 (18), ⟨10.3390/ijms231810687⟩. ⟨hal-03792024⟩


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