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Article Dans Une Revue Clinical Kidney Journal Année : 2023

Management of anaemia in French dialysis patients: results from a large epidemiological retrospective study

Résumé

Background Limited real-world data are available in Europe, especially France, regarding the therapeutic management of anaemia in patients with dialysis-dependent chronic kidney disease (DD CKD). Methods This retrospective, longitudinal, observational study was based on medical records from the MEDIAL database of not-for-profit dialysis units in France. From January to December 2016, we included eligible patients (≥18 years), with a diagnosis of CKD and receiving maintenance dialysis. Patients with anaemia were followed up for 2 years after inclusion. Patient demographic data, anaemia status, CKD-related anaemia treatments, and treatment outcomes including laboratory test results were evaluated. Results Of 1632 DD CKD patients identified from the MEDIAL database, 1286 had anaemia; 98.2% of patients with anaemia were receiving haemodialysis at index date (ID). Of patients with anaemia, 29.9% had haemoglobin (Hb) levels of 10–11 g/dL and 36.2% had levels of 11–12 g/dL at ID. Furthermore, 21.3% had functional iron deficiency and 11.7% had absolute iron deficiency. The most commonly prescribed treatments at ID for patients with DD CKD–related anaemia were intravenous (IV) iron with erythropoietin-stimulating agents (ESAs) (65.1%). Among patients initiating ESA treatment at ID or during follow-up, 347 (95.3%) reached the Hb target of 10–13 g/dL and maintained response within the target Hb range for a median duration of 113 days. Conclusions Despite combined use of ESAs and IV iron, duration within the Hb target range was short, suggesting that anaemia management can be further improved.

Dates et versions

hal-04021950 , version 1 (09-03-2023)

Identifiants

Citer

Philippe Zaoui, Cecile Courivaud, Guy Rostoker, Gabriel Choukroun, Laurence Dubel, et al.. Management of anaemia in French dialysis patients: results from a large epidemiological retrospective study. Clinical Kidney Journal, 2023, 16 (3), pp.501-511. ⟨10.1093/ckj/sfac245⟩. ⟨hal-04021950⟩

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