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Article Dans Une Revue Journal of Cellular Physiology Année : 2024

Vasorin as an actor of bone turnover?

Anne Laure Bonnet
Julien Dang
A. Michaela Krautzberger
  • Fonction : Auteur
Gael Rochefort
Claire Bardet
Heinrich Schrewe
  • Fonction : Auteur

Résumé

Bone diseases are increasing with aging populations and it is important to identify clues to develop innovative treatments. Vasn , which encodes vasorin (Vasn), a transmembrane protein involved in the pathophysiology of several organs, is expressed during the development in intramembranous and endochondral ossification zones. Here, we studied the impact of Vasn deletion on the osteoblast and osteoclast dialog through a cell Coculture model. In addition, we explored the bone phenotype of Vasn KO mice, either constitutive or tamoxifen‐inducible, or with an osteoclast‐specific deletion. First, we show that both osteoblasts and osteoclasts express Vasn. Second, we report that, in both KO mouse models but not in osteoclast‐targeted KO mice, Vasn deficiency was associated with an osteopenic bone phenotype, due to an imbalance in favor of osteoclastic resorption. Finally, through the Coculture experiments, we identify a dysregulation of the Wnt/β‐catenin pathway together with an increase in RANKL release by osteoblasts, which led to an enhanced osteoclast activity. This study unravels a direct role of Vasn in bone turnover, introducing a new biomarker or potential therapeutic target for bone pathologies.

Dates et versions

hal-04516437 , version 1 (22-03-2024)

Identifiants

Citer

Caroline Andrique, Anne Laure Bonnet, Julien Dang, Julie Lesieur, A. Michaela Krautzberger, et al.. Vasorin as an actor of bone turnover?. Journal of Cellular Physiology, 2024, ⟨10.1002/jcp.31257⟩. ⟨hal-04516437⟩
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