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Article Dans Une Revue Medical Sciences Année : 2024

Automated Single-Sperm Selection Software (SiD) during ICSI: A Prospective Sibling Oocyte Evaluation

Debbie Montjean
Marie-Hélène Godin Pagé
Carmen Pacios
  • Fonction : Auteur
Annabelle Calvé
  • Fonction : Auteur
Ghenima Hamiche
  • Fonction : Auteur

Résumé

The computer-assisted program SiD was developed to assess and select sperm in real time based on motility characteristics. To date, there are limited studies examining the correlation between AI-assisted sperm selection and ICSI outcomes. To address this limit, a total of 646 sibling MII oocytes were randomly divided into two groups as follows: the ICSI group (n = 320): ICSI performed with sperm selected by the embryologist and the ICSI-SiD group (n = 326): ICSI performed with sperm selected using SiD software. Our results show a non-significant trend towards improved outcomes in the ICSI-SiD group across various biological parameters, including fertilization, cleavage, day 3 embryo development, blastocyst development, and quality on day 5. Similarly, we observed a non-significant increase in these outcomes when comparing both groups with sperm selection performed by a junior embryologist. Embryo development was monitored using a timelapse system. Some fertilization events happen significantly earlier when SiD is used for ICSI, but no significant difference was observed in the ICSI-SiD group for other timepoints. We observed comparable cumulative early and clinical pregnancy rates after ICSI-SiD. This preliminary investigation illustrated that employing the automated sperm selection software SiD leads to comparable biological outcomes, suggesting its efficacy in sperm selection.

Dates et versions

hal-04529403 , version 1 (02-04-2024)

Identifiants

Citer

Debbie Montjean, Marie-Hélène Godin Pagé, Carmen Pacios, Annabelle Calvé, Ghenima Hamiche, et al.. Automated Single-Sperm Selection Software (SiD) during ICSI: A Prospective Sibling Oocyte Evaluation. Medical Sciences, 2024, 12 (2), pp.19. ⟨10.3390/medsci12020019⟩. ⟨hal-04529403⟩

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