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Article Dans Une Revue Next Materials Année : 2024

Biomaterial ink based on bacterial polyglucuronic acid for tissue engineering applications

Résumé

This study focuses on the development of printable biomaterial inks using a bacterial exopolysaccharide (EPS) called polyglucuronic acid (PGU), along with bacterial cellulose (BC) or methylcellulose (MC). The physical, mechanical, and biological properties of the hydrogels originating from these inks were assessed through scanning electron microscope (SEM) imaging, rheological tests, and cytocompatibility assessments. The results demonstrate that incorporating PGU into BC or MC inks enhances the shape fidelity, printability, and rigidity of the resulting 3D-printed hydrogels. Moreover, all crosslinked hydrogels based on PGU and BC or MC exhibited cytocompatibility with fibroblast cells (3T3-L1). These findings highlight the potential of the PGU/BC or MC-based biomaterial inks for various tissue engineering applications, including injectable gels, drug delivery systems, and soft tissue models. Furthermore, the study underscores the potential of using bacterial PGU as an alternative to alginate in biomaterial ink development and 3D printing.

Dates et versions

hal-04571924 , version 1 (09-05-2024)

Identifiants

Citer

Amin Shavandi, Masoud Hamidi, Oseweuba Valentine Okoro, Julia Siminska-Stanny, Maryam Hajiabbas, et al.. Biomaterial ink based on bacterial polyglucuronic acid for tissue engineering applications. Next Materials, 2024, 4, pp.100181. ⟨10.1016/j.nxmate.2024.100181⟩. ⟨hal-04571924⟩
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