Article Dans Une Revue Clinical Parkinsonism & Related Disorders Année : 2026

Effects of deep brain stimulation on non motor fluctuations in Parkinson’s disease (assessed with the NMF severity scale)

1 USJ - Université Saint-Joseph de Beyrouth / Saint Joseph University of Beirut
2 TIMONE - Hôpital de la Timone [CHU - APHM]
3 CIC 1402 - CIC de Poitiers – Centre d'investigation clinique de Poitiers (CIC 1402)
4 CHU de Poitiers [La Milétrie] - Centre hospitalier universitaire de Poitiers = Poitiers University Hospital
5 CHUV - Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne]
6 UNIL - Université de Lausanne = University of Lausanne
7 IGBMC - Institut de Génétique et de Biologie Moléculaire et Cellulaire
8 CHU Strasbourg - Centre Hospitalier Universitaire [Strasbourg]
9 LilNCog - Lille Neurosciences & Cognition - U 1172
10 CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille]
11 CHU Pitié-Salpêtrière [AP-HP]
12 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
13 Hôpital Foch [Suresnes]
14 Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL]
15 ISC-MJ - Institut des sciences cognitives Marc Jeannerod - Centre de neuroscience cognitive - UMR5229
16 CHU Bordeaux - Centre Hospitalier Universitaire de Bordeaux
17 IMN - Institut des Maladies Neurodégénératives [Bordeaux]
18 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy
19 ToNIC - Toulouse NeuroImaging Center
20 CIC 1436 - Centre d'investigation clinique de Toulouse
21 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
22 CHU Amiens-Picardie
23 CHU Clermont-Ferrand
24 UCA - Université Clermont Auvergne
25 CHU Nantes - Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
26 Service de neurologie [Rouen]
27 UNIROUEN - Université de Rouen Normandie
28 CHU Nice - Centre Hospitalier Universitaire de Nice
29 EA3279, Self-Perceived Health Assessment Research Unit, Faculty of Medicine, Marseille 13385
30 NeuroToul - Centre d’Excellence en Maladies Neurodégénératives
31 INSERM - Institut National de la Santé et de la Recherche Médicale
32 CIC Neurosciences - Centre d'investigation clinique Neurosciences [CHU Pitié Salpêtrière]
33 ICM - Institut du Cerveau = Paris Brain Institute
34 Université de Lille
35 Pôle Recherche - Département de Pharmacologie Médicale [Lille]
36 Département de neurologie [Lille]
Béchir Jarraya
Melissa Tir

Résumé

Background: Deep Brain Stimulation (DBS) of the subthalamic nucleus (STN) is a well-established treatment for motor fluctuations (MF) in Parkinson's disease (PD), but its impact on non-motor fluctuations (NMF) remains unclear. As NMFs are frequent, disabling, and affect quality of life, understanding their response to DBS is critical. Objectives: To assess the presence of NMF after STN-DBS, identify preoperative factors of improvement, and compare NMF responses to DBS and levodopa. Methods: This project is an ancillary study of the French multicenter PREDISTIM cohort. We used the validated Non-Motor Fluctuation Severity Scale (NMF2S) to evaluate NMFs one year after STN-DBS and before surgery when data were available. Evaluations were performed under standardized conditions (OFF-Dopa/OFF-Stim vs. OFF-Dopa/ON-Stim). Results: We included 284 PD patients assessed one year after STN-DBS using the NMF2S scale. Preoperative data were available for 153 patients. Evaluations were performed under standardized stimulation conditions (OFF-Dopa/OFF-Stim vs. OFF-Dopa/ON-Stim).STN-DBS led to a 41.1% reduction in NMF severity, with anxiety, concentration difficulties, and pain showing the most improvement. However, DBS effects were less pronounced than those of levodopa, especially for psychiatric symptoms. NMF improvement did not correlate with motor improvement. Among all preoperative variables, only the levodopa response in the cognitive domain was associated with post-DBS NMF benefit. Conclusions: STN-DBS significantly improves NMFs, although to a lesser extent than levodopa. The dissociation between motor and non-motor responses underscores the need for specific markers to predict NMF outcomes. These findings support the integration of NMF assessment into DBS indications and patient selection.

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hal-05510245 , version 1 (20-03-2026)

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Christian Matta, Camille Comet, Corentin Gaillard, Florent Faggianelli, Stephan Grimaldi, et al.. Effects of deep brain stimulation on non motor fluctuations in Parkinson’s disease (assessed with the NMF severity scale). Clinical Parkinsonism & Related Disorders, 2026, 14, pp.100426. ⟨10.1016/j.prdoa.2026.100426⟩. ⟨hal-05510245⟩
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