This article is dedicated to the issue of asynchronous adaptive observer-based sliding mode control for a class of nonlinear stochastic switching systems with Markovian switching. The system under examination is subject to matched uncertainties, external disturbances, and quantized outputs and is described by a TS fuzzy stochastic switching model with a Markovian process. A quantized sliding mode observer is designed, as are two modes-dependent fuzzy switching surfaces for the error and estimated systems, based on a mode dependent logarithmic quantizer. The Lyapunov approach is employed to establish sufficient conditions for sliding mode dynamics to be robust mean square stable with extended dissipativity. Moreover, with the decoupling matrix procedure, a new linear matrix inequality-based criterion is investigated to synthesize the controller and observer gains. The adaptive control technique is used to synthesize asynchronous sliding mode controllers for error and SMO systems, respectively, so as to ensure that the pre-designed sliding surfaces can be reached, and the closed-loop system can perform robustly despite uncertainties and signal quantization error.Finally, simulation results on a one-link arm robot system are provided to show potential applications as well as validate the effectiveness of the proposed scheme.